INTERACTIONS BETWEEN ELONGATION FACTORS - DISPLACEMENT OF GDP FROM TU-GDP COMPLEX BY FACTOR-TS
INTERACTIONS BETWEEN ELONGATION FACTORS - DISPLACEMENT OF GDP FROM TU-GDP COMPLEX BY FACTOR-TS
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DOI：
10.1016/0006-291x(70)90341-4
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发表时间：
1970-01-01
影响因子：
3.1
通讯作者：
WEISSBACH, H
中科院分区：
文献类型：
--
作者：
MILLER, DL;WEISSBACH, H
在含有Tu、Ts和GDP的反应混合物中增加Ts的量会导致通过凝胶过滤测量时结合为Tu-GDP的GDP量成比例地减少。似乎ts从Tu-GDP中取代了等量的GDP，形成了ts-Tu复合体。这一观察结果提供了一种从Tu中去除GDP的方法，并暗示了Ts在蛋白质生物合成中的作用。
Increasing the amount of Ts in a reaction mixture containing Tu, Ts, and GDP causes a proportionate decrease in the amount of GDP bound as Tu-GDP when measured by gel filtration. It appears that Ts displaces an equivalent amount of GDP from Tu-GDP, forming a Ts-Tu complex. This observation provides a means to remove GDP from Tu, and suggests a role for Ts in protein biosynthesis.