Review of and Updates on Hypertension in Obstructive Sleep Apnea.

Review of and Updates on Hypertension in Obstructive Sleep Apnea.
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DOI:
10.1155/2017/1848375
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发表时间:
2017
影响因子:
1.9
通讯作者:
Akbar S
Akbar S
中科院分区:
医学4区
文献类型:
--
作者:
Ahmad M;Makati D;Akbar S

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阻塞性睡眠呼吸暂停 (OSA) 与高血压 (HTN) 一样,是 21 世纪普遍存在的睡眠障碍,且肥胖发病率不断上升。大量研究表明 OSA 与心血管发病率和死亡率密切相关。有大量证据支持 OSA 与高血压 (HTN) 之间的关系。 OSA 中 HTN 的病理生理学很复杂,依赖于多种因素,如交感神经张力、肾素-血管紧张素-醛固酮系统、内皮功能障碍和压力感受器反射改变。 OSA 的治疗是多因素的,从 CPAP 到口腔矫治器、生活方式改变到抗高血压药物。 OSA 和 HTN 都需要及时诊断和治疗,以帮助解决这两种疾病导致的不断增长的心血管发病率和死亡率。
Obstructive sleep apnea (OSA) is a prevalent sleep disorder as is hypertension (HTN) in the 21st century with the rising incidence of obesity. Numerous studies have shown a strong association of OSA with cardiovascular morbidity and mortality. There is overwhelming evidence supporting the relationship between OSA and hypertension (HTN). The pathophysiology of HTN in OSA is complex and dependent on various factors such as sympathetic tone, renin-angiotensin-aldosterone system, endothelial dysfunction, and altered baroreceptor reflexes. The treatment of OSA is multifactorial ranging from CPAP to oral appliances to lifestyle modifications to antihypertensive drugs. OSA and HTN both need prompt diagnosis and treatment to help address the growing cardiovascular morbidity and mortality due to these two entities.
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发表时间: 2007-08-01
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