Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin.
Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin.
复制标题
Panax Ginseng和Crataegus Pinnatifida在人真皮成纤维细胞和健康人皮肤中的混合物的抗衰老作用。
DOI：
10.1016/j.jgr.2016.01.001
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发表时间：
2017-01
影响因子：
6.3
通讯作者：
Yi TH
中科院分区：
文献类型：
--
作者：
Hwang E;Park SY;Yin CS;Kim HT;Kim YM;Yi TH
人的皮肤在整个衰老过程中经历不同的变化，基于内在和外在因素。在称为光老化的过程中，UVB照射导致基质金属蛋白酶-1上调，然后导致胶原蛋白降解和过早老化。药用植物的混合物传统上被用作东方医学中的药物。基于先前报道的人参和羽叶三七的抗氧化特性，我们假设人参和羽叶三七（GC）的混合物将具有对抗皮肤衰老的保护作用。抗衰老活性在UVB照射下的人真皮成纤维细胞中通过使用Western印迹分析和在健康人皮肤中通过检查非侵入性测量来检查。体外研究表明，GC提高Ⅰ型前胶原的表达和减少基质金属蛋白酶-1分泌。基于非侵入性测量，皮肤粗糙度值，包括总粗糙度（R1），最大粗糙度（R2），平滑深度和平均粗糙度（R3），和全球光损伤评分改善GC应用。此外，GC改善了平滑深度（R4）的高值，这意味着GC减少了皮肤水分的损失。这些结果表明，GC可以通过抑制皱纹形成和增加人体皮肤中的水分来防止衰老。
Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P. ginseng Meyer and C. pinnatifida (GC) would have protective effects against skin aging. Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements. In vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture. These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin.