Cell and oxygen flow in arterioles controlling capillary perfusion.
Cell and oxygen flow in arterioles controlling capillary perfusion.
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小动脉中的细胞和氧气流动控制毛细血管灌注。
DOI：
10.1152/ajpheart.1993.265.5.h1682
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Sarelius,IH
中科院分区：
文献类型：
--
作者：
Sarelius,IH
在横纹肌中控制毛细血管灌注的小动脉中的血液动力学和氧运输特性的测量被用于比较进入相邻毛细血管网络的氧流量。在从单个横向小动脉连续产生的小动脉（分支1-3和最后一个分支）中进行观察。在最大扩张期间[暴露于10（-4）M腺苷（ADO）灌流5分钟后]，进入分支的平均细胞流量随着沿横动脉沿着轴向距离的增加而显著降低，从分支1的8.47 +/- 2.43 x 10（3）（SE）细胞/s降至5.56 +/- 2.14 x 10（3），3.21 +/- 1.30 x 10（3）和4.00 +/- 1.33 x 10（3）个细胞/秒。在对照期间，细胞通量在位置上没有显著差异（分支1、2和3以及最后一个分支中分别为2.21 +/- 1.12、1.31 +/- 0.42、0.97 +/- 0.31和1.23 +/- 0.40个细胞/s）。ADO期间的分支直径在不同位置之间无显著差异（分别为26.2 +/- 2.9、24.5 +/- 1.4、22.0 +/- 2.8和26.7 +/- 2.7微米）。ADO期间血红蛋白饱和度无差异（分别为59.6 +/- 2.2、60.6 +/- 2.3、60.3 +/- 2.3和61.0 +/-2.3%），而流入分支1的平均氧流量显著超过流入分支2和3以及最后一个分支的平均氧流量（分别为1.40 +/- 0.40 vs 0.60 +/- 0.17、0.53 +/- 0.22和0.66 +/- 0.22 pl/min）。在控制期间，氧流量在分支之间没有显著差异。因此，进入这些小动脉的细胞和氧气流根据它们的相对分支位置以系统的方式变化;调节过程用于使氧气供应更均匀。
Measurements of hemodynamic and oxygen transport characteristics in the arterioles that control capillary perfusion in striated muscle were used to compare oxygen flow into adjacent capillary networks. Observations were made in arterioles arising consecutively (branches 1-3 and the last branch) from a single transverse arteriole. During maximal dilation [after 5 min of exposure to superfusate with 10(-4) M adenosine (ADO)], mean cell flow into branches decreased significantly with increasing axial distance along the transverse arteriole, from 8.47 +/- 2.43 x 10(3) (SE) cells/s in branch 1 to 5.56 +/- 2.14 x 10(3), 3.21 +/- 1.30 x 10(3), and 4.00 +/- 1.33 x 10(3) cells/s in successive branches. During control, cell fluxes were not significantly different by position (2.21 +/- 1.12, 1.31 +/- 0.42, 0.97 +/- 0.31, and 1.23 +/- 0.40 cells/s in branches 1, 2, and 3 and the last branch, respectively). Branch diameters during ADO were not significantly different by position (26.2 +/- 2.9, 24.5 +/- 1.4, 22.0 +/- 2.8, and 26.7 +/- 2.7 microns, respectively). Hemoglobin saturations during ADO were not different (59.6 +/- 2.2, 60.6 +/- 2.3, 60.3 +/- 2.3, and 61.0 +/- 2.3%, respectively), whereas mean oxygen flow into branch 1 significantly exceeded that into branches 2 and 3 and the last branch (1.40 +/- 0.40 vs. 0.60 +/- 0.17, 0.53 +/- 0.22, and 0.66 +/- 0.22 pl/min, respectively). During control, oxygen flows were not significantly different between branches. Thus, both cell and oxygen flow into these arterioles vary in a systematic way dependent on their relative branch position; regulatory processes serve to make oxygen supply more uniform.