The role of adrenal and ovarian steroids in the control of serum LH and FSH.
The role of adrenal and ovarian steroids in the control of serum LH and FSH.
复制标题
肾上腺和卵巢类固醇在控制血清 LH 和 FSH 中的作用。
作者：
C. S. Campbell;N. Schwartz;M. G. Firlit
这些实验的目的是研究促性腺激素对血清类固醇环境变化的反应模式。发情周期为5天的动物在发情前期800h行双侧卵巢切除(OVX)、假卵巢切除(SOV)、肾上腺切除(ADX)、肾上腺切除加卵巢切除(ADX-OVX)，或不做手术。在发情前期0830、1300或1700h或第二天早上0830h进行尸检。整个研究在发情期重复进行。手术后48小时有额外的尸检时间。无论是动情前期还是动情后期，卵巢切除后FSH均显著升高，并在随后的24小时内维持在较高水平，而黄体生成素仅在动情前期的临界期升高，且只是暂时升高。48小时后，发情后期卵巢动物的黄体生成素开始升高。因此，在改变血清类固醇背景的条件下，证实了黄体生成素和卵泡刺激素释放的分离。此外，无论在发情前期还是发情后期，卵巢动物的雌二醇水平都与对照组没有差异。
The purpose of these experiments was to examine the pattern of gonadotropin response to alterations in the serum steroid milieu. Animals exhibiting five-day estrous cycles underwent bilateral ovariectomy (OVX), sham-ovariectomy (SOV), adrenalectomy (ADX), adrenalectomy plus ovariectomy (ADX-OVX) at 0800 h of proestrus, or were unoperated. Autopsies were done at 0830, 1300 or 1700 h of proestrus or 0830 h the following morning. The entire study was repeated on metestrus. with an additional autopsy time 48 h after surgery. After OVX on either proestrus or metestrus, FSH rose dramatically and remained high for the next 24 h. In contrast, LH rose after OVX only during the critical period on proestrus, and then only temporarily. Forty-eight hours later, LH began to rise in metestrus-OVX animals. Thus, a separation of LH and FSH release was verified under conditions of altered serum steroid backgrounds. Moreover, estradiol levels in OVX animals did not differ from control values on either proestrus or metestrus...