EPIDEMIOLOGIC OBSERVATIONS ON SPONGIFORM ENCEPHALOPATHIES IN CAPTIVE WILD ANIMALS IN THE BRITISH-ISLES
EPIDEMIOLOGIC OBSERVATIONS ON SPONGIFORM ENCEPHALOPATHIES IN CAPTIVE WILD ANIMALS IN THE BRITISH-ISLES
复制标题
DOI：
10.1136/vr.135.13.296
复制
发表时间：
1994-09-24
影响因子：
2.2
通讯作者：
CUNNINGHAM, AA
中科院分区：
文献类型：
--
作者：
KIRKWOOD, JK;CUNNINGHAM, AA
自1986年以来，在不列颠群岛的8个动物园或从8个动物园收集的8个物种的19只圈养野生动物中诊断出羊瘙痒样海绵状脑病。受影响的动物包括牛科成员：一只角羚（Tragelaphus angasi）、四只大羚羊（Taurotragus oryx）和六只大捻羚（Tragelaphus strepsiceros）、一只大羚羊（Oryx gazella）、一只阿拉伯大羚羊（Oryx leucoryx）和一只弯角大羚羊（Oryx dammah），以及猫科成员：四只猎豹（Acinonyx jubatus）和一只美洲狮（Felis concolor）。此外，德国西北部的鸵鸟（鸵鸟）的两个脚趾报告了3例病因不明的海绵状脑病。三个特点表明，其中一些病例可能是由牛海绵状脑病（BSE）引起的。首先，它们在时间和地理上与疯牛病流行一致。第二，在所有有蹄动物的详细资料中，可能是受影响的动物本身，或其出生或迁移的畜群，曾接触含有反刍动物衍生蛋白质或其他可能受污染物质的专有饲料，而所有食肉动物都曾喂食被认为不适合人类食用的牛尸体部分。第三，用从尼亚拉和从一条大捻的固定脑组织匀浆的BSE小鼠的病理结果与用BSE脑组织的BSE小鼠的病理结果相似。
Since 1986, scrapie-like spongiform encephalopathy has been diagnosed in 19 captive wild animals of eight species at or from eight zoological collections in the British Isles. The affected animals have comprised members of the family Bovidae: one nyala (Tragelaphus angasi), four eland (Taurotragus oryx), and six greater kudu (Tragelaphus strepsiceros), one gemsbok (Oryx gazella), one Arabian oryx (Oryx leucoryx), and one scimitar-horned oryx (Oryx dammah), and members of the family Felidae: four cheetah (Acinonyx jubatus) and one puma (Felis concolor). Tn addition, three cases of a spongiform encephalopathy of unknown aetiology have been reported in ostriches (Struthio camellus) from two toes in north west Germany. Three features suggest that some of these cases may have been caused by the agent of bovine spongiform encephalopathy (BSE). First, they have been temporally and geographically coincident with the BSE epidemic. Secondly, in all the ungulates for which details are available, it is possible that either the affected animal itself, or the herd into which it was born or moved, had been exposed to proprietary feeds containing ruminant-derived protein or other potentially contaminated material, and all the carnivores had been fed parts of cattle carcases judged unfit for human consumption. Thirdly, the pathological results of inoculating mice with a homogenate of fixed brain tissue from the nyala and from one greater kudu were similar to the results of inoculating mice with BSE brain tissue.