Decreased 4-1BB expression on HIV-specific CD4+T cells is associated with sustained viral replication and reduced IL-2 production
Decreased 4-1BB expression on HIV-specific CD4+T cells is associated with sustained viral replication and reduced IL-2 production
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DOI：
10.1016/j.clim.2009.03.531
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发表时间：
2009-08-01
影响因子：
8.6
通讯作者：
Palmer, Brent E.
中科院分区：
文献类型：
--
作者：
Kassu, Afework;D'Souza, Michelle;Palmer, Brent E.
慢性HIV感染者的CD 4 + T细胞功能障碍部分是由于共刺激和共抑制受体的失衡。我们报道了表达4-1BB（CD 137）或OX 40（CD 134）的病毒特异性CD 4 + T细胞比缺乏这些共刺激受体的细胞产生更多的IL-2（P
CD4+ T cell dysfunction in subjects with chronic HIV infection is in part due to an imbalance of costimulatory and coinhibitory receptors. We report that virus-specific CD4+ T cells expressing 4-1BB (CD137) or OX40 (CD134) produced more IL-2 than cells lacking these costimulatory receptors (P