PLATELETS, ENDOTHELIUM AND VASOSPASM
PLATELETS, ENDOTHELIUM AND VASOSPASM
复制标题
血小板、内皮和血管痉挛
DOI：
--
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发表时间：
1985
影响因子：
6.7
通讯作者：
P. Vanhoutte
中科院分区：
文献类型：
--
作者：
P. Vanhoutte
内皮细胞既能分泌松弛物质，也能分泌收缩物质。其中最强大的刺激释放前者是凝血酶和聚集血小板。这有助于内皮的保护作用，防止不适当的腔内血小板聚集和凝固的血管与完整的内膜。凝血酶诱导的内皮依赖性松弛已在不同物种（包括人类）的离体动脉中获得。自体血小板在狗、猪、大鼠离体血管中可诱发内皮依赖性松弛；它们可以在带有人类血小板的犬冠状动脉中获得。参与内皮依赖性松弛的主要血小板产物是5-羟色胺（5-羟色胺）和腺嘌呤核苷酸。虽然血小板活化因子（PAF）可以引起内皮依赖性松弛，但只有在浓度远高于生理条件下发生的浓度时才会这样做；由于paf拮抗剂不能阻止这种松弛，因此它们在本质上是非特异性的。介导血小板聚集释放血清素的内皮依赖性松弛的受体可分为S1~(5HT1) 5 -羟色胺能受体；作为p2y嘌呤能受体介导对腺嘌呤核苷酸的反应。在缺乏内皮细胞的情况下，血小板聚集引起血管平滑肌收缩；狗的冠状动脉由S1-like和S2~ 5 -羟色胺能受体和猪的冠状动脉由S2- 5 -羟色胺能受体的混合物介导。因此，在猪冠状动脉中，s2 - 5 -羟色胺能拮抗剂酮色胺显著增强血小板诱导的内皮依赖性松弛。在先前的（四周）损伤后，再生的猪冠状动脉内皮失去了对血清素的反应能力，无法阻止血小板聚集引起的收缩。猪冠状动脉内皮依赖性舒张是由血小板聚集引起的，而长期给予鱼肝油治疗可以增强这种舒张。这些研究强调了内皮细胞对血小板聚集引起的血管收缩（血管痉挛）的保护作用。这一作用在先前的损伤后被抑制，可以通过饮食调节来促进。
The endothelium can secrete both relaxing and contracting substances. One of the most powerful stimuli to the release of the former are thrombin and aggregating platelets. This contributes to the protective role of the endothelium against inappropriate intraluminal platelet aggregation and coagulation in blood vessels with an intact intima. Thrombin-induced, endothelium-dependent relaxations have been obtained in isolated arteries of different species, including humans. Endothelium-dependent relaxations can be evoked by autologous platelets in isolated blood vessels of the dog, pig and rat; they can be obtained in canine coronary arteries with human platelets. The major platelet-products involved in these endothelium-dependent relaxations are 5-hydroxytryptamine (serotonin) and the adenine nucleotides. Although platelet-activating factor (PAF) can evoke endothelium-dependent relaxation it only does so at concentrations much higher than those occurring under physiological conditions; since the relaxations are not prevented by PAF-antagonists, they are non-specific in nature.The receptor mediating the endothelium-dependent relaxations to serotonin released from the aggregating platelets can be subtyped as a S1~(5HT1) serotonergic receptor;those mediating the response to the adenine nucleotides as P2y-purinergic receptors. In the absence of the endothelium aggregating platelets cause contractions of vascular smooth muscle; these are mediated by a mixture of S1-like and S2~serotoner-gic receptors in coronary arteriesof the dog, and by S2-serotonergic receptors in those of the pig. Thus, in the porcine coronary artery, the S2-serotonergic antagonist ketanserin markedly enhances the platelet-induced endothelium-dependent relaxation. After previous (four weeks) injury, the regenerated endothelium of the porcine coronary artery loses the ability to respond to serotonin,and is unable to prevent the constrictionsevoked by aggregating platelets. The endothelium-dependent relaxations of porcine coronary arteries evoked by aggregating platelets are potentiated by chronic treatmentof the donor animals with cod liver oil. These studies emphasize the protective roleof the endothelial cells against the vasoconstriction (vasospasm) induced by aggregating platelets. This role is depressed after previous injury, and can be facilitatedby dietary adj ustments.
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影响因子：
15.9
作者：
MARCUS, AJ;WEKSLER, BB;BROEKMAN, MJ
通讯作者：
BROEKMAN, MJ
冠状动脉痉挛：原因和后果（科学家的观点）。
影响因子：
8.9
作者：
Shepherd,JT;Vanhoutte,PM
通讯作者：
Vanhoutte,PM
前列腺素内过氧化物在血小板和内皮细胞之间的单向转移。
DOI：
10.1172/jci111296
发表时间：
1984
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Schafer,AI;Crawford,DD;GimbroneJr,MA
通讯作者：
GimbroneJr,MA
低血压和血小板血清素反应所需的血小板激活因子（1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）的结构特征。
DOI：
--
发表时间：
1982
期刊：
Research communications in chemical pathology and pharmacology
影响因子：
--
作者：
Blank,ML;Cress,EA;Lee,TC;Malone,B;Surles,JR;Piantadosi,C;Hajdu,J;Snyder,F
通讯作者：
Snyder,F