Iraq dust is respirable, sharp, and metal-laden and induces lung inflammation with fibrosis in mice via IL-2 upregulation and depletion of regulatory T cells.
Iraq dust is respirable, sharp, and metal-laden and induces lung inflammation with fibrosis in mice via IL-2 upregulation and depletion of regulatory T cells.
复制标题
伊拉克粉尘可吸入、锋利且富含金属，可通过 IL-2 上调和调节性 T 细胞耗竭而诱发小鼠肺部炎症和纤维化。
DOI：
10.1097/jom.0000000000000119
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发表时间：
2014
影响因子：
3.2
通讯作者：
Hamidi,SayyedA
中科院分区：
文献类型：
--
作者：
Szema,AnthonyM;Reeder,RichardJ;Harrington,AndreaD;Schmidt,Millicent;Liu,Jingxuan;Golightly,Marc;Rueb,Todd;Hamidi,SayyedA
Objectives：Determine whether surface dust grab samples taken from a large military base in Iraq are toxic and respirable.Methods：X-射线衍射矿物质含量，X-射线荧光元素含量，在体内小鼠粉尘的组织学变化的评估挑战，支气管肺泡灌洗细胞因子，偏光显微镜在肺组织中的晶体，和荧光激活细胞分选细胞表面和细胞内marker were used.Results：Camp Victory，伊拉克灰尘在战时采取包含可吸入颗粒物2.5微米的大小，构成颗粒物空气污染。尘埃颗粒是有棱角的，有锋利的边缘。存在微量金属（包括钛）、钙和硅。气道滴入粉尘的小鼠肺内有极化结晶，并有隔膜炎症。胸腺和脾脏中的调节性T细胞（CD 4 + CD 25 + FOXP 3+）减少。白细胞介素-2（IL-2）是上调支气管肺泡灌洗液。结论：可吸入的伊拉克粉尘导致肺部炎症小鼠中看到的可极化晶体，这似乎是钛的患者相似。
Objectives:Determine whether surface dust grab samples taken from a large military base in Iraq are toxic and respirable.Methods:X-ray diffraction for mineral content, x-ray fluorescence for elemental content, in vivo mouse dust challenges for assessment of histological changes, bronchoalveolar lavage for cytokines, polarizing light microscopy for crystals in lung tissue, and Fluorescence Activated Cell Sorting for cell surface and intracellular markers were utilized.Results:Camp Victory, Iraq dust taken during wartime contains respirable particles 2.5 microns in size, constituting particulate matter air pollution. Dust particles are angular and have sharp edges. Trace metals (including titanium) calcium and silicon are present. Mice with airway instillation of dust have polarizable crystals in lung and septate inflammation. Regulatory T cells (CD4+ CD25+ FOXP3+) are decreased in thymus and spleen. Interleukin-2 (IL-2) is upregulated in bronchoalveolar lavage.Conclusions:Respirable Iraq dust leads to lung inflammation in mice similar to that seen in patients with polarizable crystals, which seem to be titanium.