Host and tumor responses to increasing levels of intravenous nutritional support.
Host and tumor responses to increasing levels of intravenous nutritional support.
复制标题
宿主和肿瘤对增加静脉营养支持水平的反应。
作者：
M. Popp;Wagner Sc;Brito Oj
肿瘤和宿主对静脉输注营养基质速率增加的反应尚不清楚。生长中的Fischer 344大鼠进行肉瘤移植（第0天），无菌放置上级腔静脉导管（第14天），并输注营养充足的溶液（第18 - 28天）。输注率（正常热量摄入百分比）分别为33%、67%、100%、133%和167%。对照组包括喂食相同固体口服饮食的荷瘤（T）组和与T大鼠相同治疗的非荷瘤大鼠。除T-167%组无一存活外，每组的6只大鼠中至少有5只存活至10天实验结束。平均肿瘤重量、胴体重量、肿瘤重量/胴体重量比和肿瘤重量/瘦体重比随底物输注速率线性增加。肿瘤的成分研究显示，所有肿瘤的蛋白质、脂肪和水的含量相似。胴体组成的研究表明，随着底物输注量的增加，脂肪积累速率增加，蛋白质积累速率恒定。这些数据表明，随着底物输注速率的增加，肿瘤生长比瘦宿主尸体增加的程度更大，并且不耐受高水平的底物输注。
Responses of tumor and host to increasing rates Of intravenous infusion of nutritional substrate remain undefined. Growing Fischer 344 rats underwent sarcoma transplant (day 0), aseptic placement of a superior vena cava catheter (day 14), and infusion with a nutritionally adequate solution (days 18 to 28). Rates of infusion (percentage of normal caloric intake) were 33%, 67%, 100%, 133%, and 167%. Controls included a tumor-bearing (T) group fed an identical solid oral diet and non-tumor-bearing rats treated identically to T rats. At least five of six rats survived the 10-day experiment from each group except the T-167% group, none of which survived. The mean tumor weight, carcass weight, ratio of tumor weight: carcass weight, and ratio of tumor weight: lean body mass increased linearly with the rate of substrate infusion. Composition studies of tumor revealed similar content of protein, fat, and water for all tumors. Studies of carcass composition revealed an increase in rate of fat accumulation and a constant rate of protein accumulation with increase in substrate infusion. These data indicate that tumor growth increases to a greater extent than the lean host carcass with increasing rate of substrate infusion and that high levels of substrate infusion are not tolerated.