Associations between Leukocyte Counts and Cardiovascular Disease Risk Factors in Apparently Healthy Japanese Men
Associations between Leukocyte Counts and Cardiovascular Disease Risk Factors in Apparently Healthy Japanese Men
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DOI：
10.3177/jnsv.58.181
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发表时间：
2012-06-01
影响因子：
1.6
通讯作者：
Goda, Toshinao
中科院分区：
文献类型：
--
作者：
Mochizuki, Kazuki;Miyauchi, Rie;Goda, Toshinao
据报道，白细胞计数增加，特别是白色血细胞和中性粒细胞计数增加，与急性和中度冠状动脉疾病受试者的心血管疾病（CVD）发生率和死亡率增加相关。然而，很少有报道确定白细胞亚群（即，白色血细胞、中性粒细胞、单核细胞、淋巴细胞、嗜碱性粒细胞和嗜酸性粒细胞）计数和CVD风险因素。在这项研究中，我们研究了白细胞亚群计数和CVD危险因素之间的关系，在明显健康的日本男性。我们对参加健康检查的男性进行了一项横断面研究，并选择了那些没有接受代谢疾病治疗的人。我们通过多元线性回归（MLR）分析和协方差分析（ANCOVA）确定白细胞亚群计数与CVD危险因素之间的关系。总体而言，招募了3，576例年龄为49.3 ± 5.75（范围，40-59）岁的受试者。MLR和ANCOVA显示，白色血细胞、中性粒细胞、单核细胞计数与高密度脂蛋白胆固醇（HDL-C）降低和C-反应蛋白水平升高相关，淋巴细胞计数与血脂异常呈正相关（即，HDL-C降低、低密度脂蛋白胆固醇升高和三酰甘油（TG）升高），嗜碱性粒细胞计数与TG和肝损伤标志物水平升高相关（即，丙氨酸氨基转移酶）。我们的研究结果表明，在表面健康的日本男性中，白细胞亚群计数与心血管疾病危险因素有不同的相关性。
Increased leukocyte counts, particularly white blood cell and neutrophil counts, are reportedly associated with increased incidence of cardiovascular diseases (CVD) and mortality in subjects with acute and moderate coronary diseases. However, few reports have determined the associations between leukocyte subset (i.e., white blood cells, neutrophils, monocytes, lymphocytes, basophils and eosinophils) counts and CVD risk factors. In this study, we examined the associations between leukocyte subset counts and CVD risk factors in apparently healthy Japanese men. We conducted a cross-sectional study of men who participated in health checkups, and selected those who were not being treated for metabolic diseases. We determined associations between leukocyte subset counts and CVD risk factors by multivariate linear regression (MLR) analysis and analysis of covariance (ANCOVA). Overall, 3,576 subjects aged 49.3 +/- 5.75 (range, 40-59) y were recruited. MLR and ANCOVA showed that white blood cell, neutrophil, monocyte counts are associated with decreased high-density lipoprotein cholesterol (HDL-C) and increased C-reactive protein levels, the lymphocyte count is positively associated with lipid abnormalities (i.e., decreased HDL-C, increased low-density lipoprotein cholesterol and increased triacylglycerol (TG)), and the basophil count is associated with increased TG and liver injury marker levels (i.e., alanine aminotransferase). Our results in this study demonstrated that leukocyte subset counts showed differential associations with CVD risk factors in apparently healthy Japanese men.