microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma
microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma
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DOI：
10.3892/ijo.2014.2349
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发表时间：
2014-06-01
影响因子：
5.2
通讯作者：
Seki, Naohiko
中科院分区：
文献类型：
--
作者：
Kikkawa, Naoko;Kinoshita, Takashi;Seki, Naohiko
我们最近对下咽鳞状细胞癌（HSCC）中microRNA（miRNA）表达特征的研究显示，microRNA-504（miR-504）在HSCC组织中表达显著下调，提示该miRNA是一种候选的肿瘤抑制因子。然而，之前的多项报道表明miR-504通过靶向TP 53而具有致癌功能。本研究的目的是研究miR-504在癌细胞中的功能意义，并确定HSCC细胞中由该miRNA调控的新靶点。首先，我们证实了miR-504在HSCC临床标本中表达下调（P
Our recent study of the microRNA (miRNA) expression signature of hypopharyngeal squamous cell carcinoma (HSCC) revealed that microRNA-504 (miR-504) is significantly downregulated in HSCC tissues, suggesting that this miRNA is a candidate tumor suppressor. However, several previous reports indicated that miR-504 has an oncogenic function through targeting TP53. The aim of this study was to investigate the functional significance of miR-504 in cancer cells and to identify novel targets regulated by this miRNA in HSCC cells. First, we confirmed the downregulation of miR-504 in HSCC clinical specimens (P