Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward?
Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward?
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VEGF/VEGFR与免疫细胞和癌细胞的关系：蹒跚还是向前？
DOI：
10.20892/j.issn.2095-3941.2015.0070
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发表时间：
2016-06
影响因子：
5.5
通讯作者：
Ren XB
中科院分区：
文献类型：
--
作者：
Li YL;Zhao H;Ren XB
血管内皮生长因子（Vascular endothelial growth factor， VEGF）主要被称为促血管生成因子，是影响血管内皮最重要的生长和存活因子之一。然而，最近的研究表明，VEGF在免疫环境中也起着至关重要的作用。除了VEGF和VEGF受体（VEGFRs）传统的生长因子作用外，它们还与各种免疫细胞有着复杂的关系。据报道，VEGF还能抑制造血过程中免疫细胞的分化和功能。树突状细胞（dc）、巨噬细胞和淋巴细胞进一步表达某些类型的VEGF受体。VEGF也可以通过自分泌途径由肿瘤细胞分泌，并能刺激肿瘤干细胞的功能。这篇综述将为我们理解VEGF/VEGFR信号在免疫和癌症环境中的作用提供一个范式转变。
Vascular endothelial growth factor (VEGF) is primarily known as a proangiogenic factor and is one of the most important growth and survival factors affecting the vascular endothelium. However, recent studies have shown that VEGF also plays a vital role in the immune environment. In addition to the traditional growth factor role of VEGF and VEGF receptors (VEGFRs), they have a complicated relationship with various immune cells. VEGF also reportedly inhibits the differentiation and function of immune cells during hematopoiesis. Dendritic cells (DCs), macrophages, and lymphocytes further express certain types of VEGF receptors. VEGF can be secreted as well by tumor cells through the autocrine pathway and can stimulate the function of cancer stemness. This review will provide a paradigm shift in our understanding of the role of VEGF/VEGFR signaling in the immune and cancer environment.