Stimulus features, resetting curves, and the dependence on adaptation.

Stimulus features, resetting curves, and the dependence on adaptation.
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DOI:
10.1007/s10827-012-0433-5
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发表时间:
2013-06
影响因子:
1.2
通讯作者:
Ermentrout, G. Bard
Ermentrout, G. Bard
中科院分区:
医学4区
文献类型:
--
作者:
Arthur, Joseph G.;Burton, Shawn D.;Ermentrout, G. Bard

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我们推导了尖峰触发协方差(STC)与神经振荡器的相位重置曲线(PRC)之间的关系式。我们用它来说明PRC形状的变化如何改变神经元对不同刺激特征的敏感性,这些特征是STC的特征向量。我们计算了一些生物物理模型的PRC和STC。我们比较了两个参数的PRC族的STC和它们的光谱性质。令人惊讶的是,PRC的偏斜对STC的频谱和形状的影响比PRC的双峰性(在同步特性中起着重要作用)更大。最后,我们将STC直接与尖峰触发的平均值相关联,并将该理论应用于嗅球二尖瓣细胞的记录。
We derive a formula that relates the spike-triggered covariance (STC) to the phase resetting curve (PRC) of a neural oscillator. We use this to show how changes in the shape of the PRC alter the sensitivity of the neuron to different stimulus features, which are the eigenvectors of the STC. We compute the PRC and STC for some biophysical models. We compare the STCs and their spectral properties for a two-parameter family of PRCs. Surprisingly, the skew of the PRC has a larger effect on the spectrum and shape of the STC than does the bimodality of the PRC (which plays a large role in synchronization properties). Finally, we relate the STC directly to the spike-triggered average and apply this theory to an olfactory bulb mitral cell recording.
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