CORTICAL CELLULAR PHENOMENA IN EXPERIMENTAL EPILEPSY - ICTAL MANIFESTATIONS
CORTICAL CELLULAR PHENOMENA IN EXPERIMENTAL EPILEPSY - ICTAL MANIFESTATIONS
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DOI：
10.1016/0014-4886(64)90026-3
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发表时间：
1964-01-01
影响因子：
5.3
通讯作者：
MARSAN, CA
中科院分区：
文献类型：
--
作者：
MATSUMOTO, H;MARSAN, CA
在猫大脑皮层建立致痫“病灶”后，用表面电极同时监测有组织节律电图癫痫发作的发展和过程，对涉及的元素进行细胞内分析。神经元根据其行为分为主动和被动。在前者中，观察到膜极化的变化，其特征在于发作发作的各个阶段。先前存在的阵发性超极化转变在发病时消失，并出现显著的后去极化。在紧张性阶段，膜电位显着降低，有节奏的振荡（或很少没有）动作电位出现以上持续过度去极化膜电位水平。阵挛相对应于一个缓慢的复极化过程，该事件的结束似乎是由于失活，而不是真正的膜超极化。有些神经元似乎只在癫痫发作的后期才被激活。
After establishing an epileptogenic "focus" in the cat''s cerebral cortex, an intracellular analysis from the involved elements was carried out during the development and course of the organized rhythmical electrographic seizures simultaneously monitored with surface electrodes. Neurons were classified on the basis of their behavior as active or passive. In the former, changes in membrane polarization were observed which characterized the various phases of the ictal episode. The previously present paroxysmal hyperpolarization shifts disappear at the onset and a prominent afterdepolarization develops. During the tonic phase the membrane potential markedly decreases and rhythmical oscillations with (or rarely without) action potentials appears above a sustained excessively depolarized membrane potential level. The clonic phase corresponds to a slow repolarization process and the end of the episode seems to be due to inactivation rather than to true membrane hyperpolarization. Some neurons appear to be activated only in the later phases of the seizure.