Cerium oxide nanoparticles: green synthesis and biological applications.
Cerium oxide nanoparticles: green synthesis and biological applications.
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DOI：
10.2147/ijn.s124855
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发表时间：
2017
影响因子：
8
通讯作者：
Darroudi M
中科院分区：
文献类型：
--
作者：
Charbgoo F;Ahmad MB;Darroudi M
CeO2纳米颗粒（NPs）在生物学和医学领域显示出很好的治疗前景。CeO2-NPs的物理化学性质，如大小、在液体中的团聚状态和表面电荷等，在NP与靶细胞的最终相互作用中起着重要作用。近年来，利用天然基质和有机基质作为稳定剂，通过多种生物定向方法合成了CeO2-NPs，以制备具有生物相容性的CeO2-NPs，从而解决了CeO2-NPs在安全性方面的挑战，为其在生物医学中的有效应用提供了合适的条件。本文综述了不同的绿色合成策略及其优势和需要克服的挑战。此外，本文还对近年来CeO2-NPs在生物和医学领域的潜在应用进行了综述。利用生物相容性的CeO2-NPs可能会大大改善结果，并有望有效的神经退行性治疗和纳米生物技术的多种应用。
CeO2 nanoparticles (NPs) have shown promising approaches as therapeutic agents in biology and medical sciences. The physicochemical properties of CeO2-NPs, such as size, agglomeration status in liquid, and surface charge, play important roles in the ultimate interactions of the NP with target cells. Recently, CeO2-NPs have been synthesized through several bio-directed methods applying natural and organic matrices as stabilizing agents in order to prepare biocompatible CeO2-NPs, thereby solving the challenges regarding safety, and providing the appropriate situation for their effective use in biomedicine. This review discusses the different green strategies for CeO2-NPs synthesis, their advantages and challenges that are to be overcome. In addition, this review focuses on recent progress in the potential application of CeO2-NPs in biological and medical fields. Exploiting biocompatible CeO2-NPs may improve outcomes profoundly with the promise of effective neurodegenerative therapy and multiple applications in nanobiotechnology.