Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition.
Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition.
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DOI：
10.3389/fnmol.2021.664912
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发表时间：
2021
影响因子：
4.8
通讯作者：
Ossowski S
中科院分区：
文献类型：
--
作者：
Espeso-Gil S;Holik AZ;Bonnin S;Jhanwar S;Chandrasekaran S;Pique-Regi R;Albaigès-Ràfols J;Maher M;Permanyer J;Irimia M;Friedländer MR;Pons-Espinal M;Akbarian S;Dierssen M;Maass PG;Hor CN;Ossowski S
在早期发育中，环境触发记忆表观基因组程序，导致记忆和学习经验，从而将认知表型赋予成年期。为了揭示环境刺激如何影响表观基因组和基因组组织，我们在不断接受新刺激的幼鼠中使用了环境富集（EE）范式。我们分析了整个皮层的表观基因组和染色质结构，并通过深度测序技术对神经元进行了分类。具体来说，我们研究了染色质可及性、基因和蛋白质调控、三维基因组构象，并结合预测的增强子和染色质相互作用。我们发现染色质可及性增加，转录因子结合（包括ctcf介导的绝缘），H3K36me3和H3K79me2的差异占用，以及神经元发育所需的转录程序的变化。EE刺激通过诱导7号和17号染色体（染色体间）之间增加接触导致局部基因组重组。我们的研究结果支持这样一种观点，即电子电信号诱导的学习和记忆过程与表观基因组和基因组组织直接相关。
In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the epigenome and genome organization, we used the paradigm of environmental enrichment (EE) in young mice constantly receiving novel stimulation. We profiled epigenome and chromatin architecture in whole cortex and sorted neurons by deep-sequencing techniques. Specifically, we studied chromatin accessibility, gene and protein regulation, and 3D genome conformation, combined with predicted enhancer and chromatin interactions. We identified increased chromatin accessibility, transcription factor binding including CTCF-mediated insulation, differential occupancy of H3K36me3 and H3K79me2, and changes in transcriptional programs required for neuronal development. EE stimuli led to local genome re-organization by inducing increased contacts between chromosomes 7 and 17 (inter-chromosomal). Our findings support the notion that EE-induced learning and memory processes are directly associated with the epigenome and genome organization.
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影响因子：
3.4
作者：
DaSilva LL;Wall MJ;P de Almeida L;Wauters SC;Januário YC;Müller J;Corrêa SA
通讯作者：
Corrêa SA
DOI：
10.1523/jneurosci.1815-08.2008
发表时间：
2008-07-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chen YJ;Johnson MA;Lieberman MD;Goodchild RE;Schobel S;Lewandowski N;Rosoklija G;Liu RC;Gingrich JA;Small S;Moore H;Dwork AJ;Talmage DA;Role LW
通讯作者：
Role LW
影响因子：
14.9
作者：
Chen C;Ridzon DA;Broomer AJ;Zhou Z;Lee DH;Nguyen JT;Barbisin M;Xu NL;Mahuvakar VR;Andersen MR;Lao KQ;Livak KJ;Guegler KJ
通讯作者：
Guegler KJ
影响因子：
16.2
作者：
Edbauer, Dieter;Neilson, Joel R.;Foster, Kelly A.;Wang, Chi-Fong;Seeburg, Daniel P.;Batterton, Matthew N.;Tada, Tomoko;Dolan, Bridget M.;Sharp, Phillip A.;Sheng, Morgan
通讯作者：
Sheng, Morgan
影响因子：
2.9
作者：
Ferrer-Ferrer M;Dityatev A
通讯作者：
Dityatev A