fMRI activation in a visual-perception task: Network of areas detected using the general linear model and independent components analysis
fMRI activation in a visual-perception task: Network of areas detected using the general linear model and independent components analysis
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DOI：
10.1006/nimg.2001.0921
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发表时间：
2001-11-01
期刊：
影响因子：
5.7
通讯作者：
Pearlson, GD
中科院分区：
文献类型：
--
作者：
Calhoun, VD;Adali, T;Pearlson, GD
无运动视觉感知测试，修订版（MVPT-R），提供了一个视觉感知处理的措施。它涉及不同的认知元素，包括视觉辨别，空间关系和心理旋转。我们适应MVPT-R的事件相关的功能性AM（fMRI）的环境，以调查这些认知元素的相互关系所涉及的大脑区域。采用两种互补的分析方法来表征fMRI数据：（a）基于时程模型和血流动力学响应估计的一般线性模型SPM方法和（B）独立成分分析（伊卡），它不限制时程本身的特定形状，尽管我们确实要求它至少与任务暂时相关。此外，我们以一种新颖的方式实现伊卡，以创建与SPM组结果相比较的组平均值。这两种方法产生了相似但不完全相同的结果，并检测到一个强大的激活视觉，下顶叶，额叶眼区以及丘脑和小脑的网络。SPM似乎是更敏感的方法，并有一个完善的理论方法阈值。伊卡方法将功能元件分离到单独的地图中，并识别出响应于呈现的事件而具有扩展激活的额外区域。结果表明，功能磁共振成像数据的互补分析的效用，并建议小脑可能发挥重要作用，在视觉感知处理。此外，研究结果表明，功能之间的连接额眼领域和前额叶和顶叶区域。(C)北京：科学出版社.
The Motor-Free Visual Perception Test, revised (MVPT-R), provides a measure of visual perceptual processing. It involves different cognitive elements including visual discrimination, spatial relationships, and mental rotation. We adapted the MVPT-R to an event-related functional AM (fMRI) environment to investigate the brain regions involved in the interrelation of these cognitive elements. Two complementary analysis methods were employed to characterize the fMRI data: (a) a general linear model SPM approach based upon a model of the time course and a hemodynamic response estimate and (b) independent component analysis (ICA), which does not constrain the specific shape of the time course per se, although we did require it to be at least transiently task-related. Additionally, we implemented ICA in a novel way to create a group average that was compared with the SPM group results. Both methods yielded similar, but not identical, results and detected a network of robustly activated visual, inferior parietal, and frontal eye-field areas as well as thalamus and cerebellum. SPM appeared to be the more sensitive method and has a well-developed theoretical approach to thresholding. The ICA method segregated functional elements into separate maps and identified additional regions with extended activation in response to presented events. The results demonstrate the utility of complementary analyses for fMRI data and suggest that the cerebellum may play a significant role in visual perceptual processing. Additionally, results illustrate functional connectivity between frontal eye fields and prefrontal and parietal regions. (C) 2001 Academic Press.