Acute beetroot juice supplementation on sympathetic nerve activity: a randomized, double-blind, placebo-controlled proof-of-concept study
Acute beetroot juice supplementation on sympathetic nerve activity: a randomized, double-blind, placebo-controlled proof-of-concept study
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DOI：
10.1152/ajpheart.00163.2017
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发表时间：
2017-07-01
影响因子：
4.8
通讯作者：
Millar, Philip J.
中科院分区：
文献类型：
--
作者：
Notay, Karambir;Incognito, Anthony V.;Millar, Philip J.
急性膳食硝酸盐（NO3-）补充可降低健康血压正常者静息血压。这种反应归因于一氧化氮生物利用度增加和外周血管舒张，尽管一氧化氮也能抑制中枢交感神经流出。我们假设急性饮食中使用甜菜根（BR）汁补充NO3-可以降低休息和运动时的血压和肌肉交感神经活动（MSNA）。在双盲、随机、交叉设计中，14名参与者（7名男性和7名女性，年龄：25 +/- 10岁）在摄入70ml高NO3-（类似于6.4 mmol NO3-） BR或NO3-衰竭BR安慰剂（PL，类似于0.0055 mmol NO3-）前后（165-180分钟）接受了血压和MSNA测量。静握力2 min（最大自主收缩30%）时，采集血压和肌中蛋白钠。休息MSNA破裂的变化频率(3 + / - 5和3 + / - 4脉冲/分钟,P = 0.001)和破裂的发病率(4 + / - 7和4 + / - 5暴/ 100心脏跳动时,P = 0.002) BR和PL后较低,而收缩压(1 + / - 5和2 + / - 5毫米汞柱,P = 0.30)和舒张压(4 + / - 5和5 + / - 7毫米汞柱,P = 0.68),以及自发性动脉交感神经压力反射敏感性(P = 0.95)没有不同。在静态握力时，BR与PL相比，MSNA爆发发生率（1 +/- 8 vs 8 +/- 9次/ 100次心跳，P = 0.04）的变化更低，而MSNA爆发频率（6 +/- 6 vs 11 +/- 10次/min， P = 0.11）、收缩压（11 +/- 7 vs 12 +/- 8 mmHg, P = 0.94）和舒张压（11 +/- 4 vs 11 +/- 4 mmHg, P = 0.60）没有差异。总的来说，这些数据证明了急性BR补充可以减少休息和运动时中枢交感神经流出的原理。膳食补充NO3-可能是针对临床人群过度交感神经流出的一种新的干预措施。
Acute dietary nitrate (NO3-) supplementation reduces resting blood pressure in healthy normotensives. This response has been attributed to increased nitric oxide bioavailability and peripheral vasodilation, although nitric oxide also tonically inhibits central sympathetic outflow. We hypothesized that acute dietary NO3- supplementation using beetroot (BR) juice would reduce blood pressure and muscle sympathetic nerve activity (MSNA) at rest and during exercise. Fourteen participants (7 men and 7 women, age: 25 +/- 10 yr) underwent blood pressure and MSNA measurements before and after (165-180 min) ingestion of 70ml high-NO3- (similar to 6.4 mmol NO3- ) BR or NO3--depleted BR placebo (PL; similar to 0.0055 mmol NO3-) in a double-blind, randomized, crossover design. Blood pressure and MSNA were also collected during 2 min of static handgrip (30% maximal voluntary contraction). The changes in resting MSNA burst frequency (-3 +/- 5 vs. 3 +/- 4 bursts/min, P = 0.001) and burst incidence (-4 +/- 7 vs. 4 +/- 5 bursts/100 heart beats, P = 0.002) were lower after BR versus PL, whereas systolic blood pressure (-1 +/- 5 vs. 2 +/- 5 mmHg, P = 0.30) and diastolic blood pressure (4 +/- 5 vs. 5 +/- 7 mmHg, P = 0.68) as well as spontaneous arterial sympathetic baroreflex sensitivity (P = 0.95) were not different. During static handgrip, the change in MSNA burst incidence (1 +/- 8 vs. 8 +/- 9 bursts/ 100 heart beats, P = 0.04) was lower after BR versus PL, whereas MSNA burst frequency (6 +/- 6 vs. 11 +/- 10 bursts/min, P = 0.11) as well as systolic blood pressure (11 +/- 7 vs. 12 +/- 8 mmHg, P = 0.94) and diastolic blood pressure (11 +/- 4 vs. 11 +/- 4 mmHg, P = 0.60) were not different. Collectively, these data provide proof of principle that acute BR supplementation can decrease central sympathetic outflow at rest and during exercise. Dietary NO3- supplementation may represent a novel intervention to target exaggerated sympathetic outflow in clinical populations.