Aging affects the cardiovascular responses to cold stress in humans
Aging affects the cardiovascular responses to cold stress in humans
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DOI：
10.1152/japplphysiol.00605.2009
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发表时间：
2009-10-01
影响因子：
3.3
通讯作者：
Monahan, Kevin D.
中科院分区：
文献类型：
--
作者：
Hess, Kari L.;Wilson, Thad E.;Monahan, Kevin D.
Hess KL、Wilson TE、Sauder CL、Gao Z、Ray CA、Monahan KD。衰老会影响人类心血管对冷应激的反应。 J Appl Physiol 107: 1076-1082, 2009。首次发表于 2009 年 8 月 13 日； doi:10.1152/japplphyol.00605.2009.-心血管相关死亡率在寒冷的冬季达到峰值，尤其是老年人。对寒冷暴露的急性生理反应，例如血压升高，可能会导致这些关联。为了确定非体内降低体温的冷应激的升压效应（升压反应）是否随着年龄的增长而增强，我们测量了 12 名年轻 [25 +/- 1 (SE) 岁] 和 12 名老年人（65 +/- 2 岁）通过注水服进行 20 分钟表面皮肤冷却的生理反应。我们发现，浅表皮肤冷却会导致年轻人和老年人的静息血压升高（升压反应；P < 0.05）。然而，这种升压反应的强度（收缩压和平均血压）在老年人中高出两倍以上（与年轻人相比，P < 0.05）。外周（肱动脉）和中央（主动脉中估计）测量部位的升压反应幅度相似。回归分析显示，主动脉脉搏波速度（冷却前获得的中央动脉僵硬度的量度）是老年人对浅表皮肤冷却的升压反应增加的最佳预测因子，解释了其 63% 的变异性。这些结果表明，随着年龄的增长，人类对非内部体温降低的冷应激有更大的升压反应，这可能是由中央动脉僵硬度水平增加介导的。
Hess KL, Wilson TE, Sauder CL, Gao Z, Ray CA, Monahan KD. Aging affects the cardiovascular responses to cold stress in humans. J Appl Physiol 107: 1076-1082, 2009. First published August 13, 2009; doi:10.1152/japplphysiol.00605.2009.-Cardiovascular-related mortality peaks during cold winter months, particularly in older adults. Acute physiological responses, such as increases in blood pressure, in response to cold exposure may contribute to these associations. To determine whether the blood pressure-raising effect ( pressor response) of non-internal body temperature-reducing cold stress is greater with age, we measured physiological responses to 20 min of superficial skin cooling, via water-perfused suit, in 12 younger [25 +/- 1 (SE) yr old] and 12 older (65 +/- 2 yr old) adults. We found that superficial skin cooling elicited an increase in blood pressure from resting levels (pressor response; P < 0.05) in younger and older adults. However, the magnitude of this pressor response (systolic and mean blood pressure) was more than twofold higher in older adults (P < 0.05 vs. younger adults). The magnitude of the pressor response was similar at peripheral (brachial) and central (estimated in the aorta) measurement sites. Regression analysis revealed that aortic pulse wave velocity, a measure of central arterial stiffness obtained before cooling, was the best predictor of the increased pressor response to superficial skin cooling in older adults, explaining similar to 63% of its variability. These results indicate that there is a greater pressor response to non-internal body temperature-reducing cold stress with age in humans that may be mediated by increased levels of central arterial stiffness.