Schizophrenia polygenic risk score and psychotic risk detection-Authors' reply.
Schizophrenia polygenic risk score and psychotic risk detection-Authors' reply.
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精神分裂症多基因风险评分和精神病风险检测-作者回复。
DOI：
10.1016/s2215-0366(17)30052-4
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Riglin L
中科院分区：
文献类型：
--
作者：
Riglin L
Lucy Riglin和他的同事1表明，携带精神分裂症相关风险等位基因的儿童，其群体频率高于1%，容易出现青春期前发育障碍。在控制了社会阶层和性别后，精神分裂症的多基因风险分数在7-9岁时仍与操作智商、言语可理解性和流利性、任性行为有关，在4岁时与社交困难和行为问题有关。这些发现与家族性高危研究、前瞻性队列研究和回溯性研究一致，这些研究表明精神分裂症在发病前有神经行为改变。2 Riglin和他的同事们的研究目的1是强调这些不同的表型表现中的一些可能表明精神分裂症的遗传易感性。然而，作者明确指出，这些损害是一种遗传责任，而不是疾病的前兆，需要进一步研究，以区分反映多效性的责任的早期表现与那些与精神分裂症相关的发育损害。关于精神分裂症遗传风险的经验知识正在迅速扩大，但许多空白限制了我们使用基因数据预测未来精神病的能力。几个相互作用的个人和环境风险或保护
Lucy Riglin and colleagues1 showed that children carrying schizophrenia-associated risk alleles with a population frequency higher than 1% are predisposed to have prepubertal developmental impairments. After controlling for social class and sex, schizophrenia polygenic risk scores remained associated with performance IQ, speech intelligibility and fluency, and headstrong behaviour at age 7–9 years, and with social difficulties and behaviour problems at age 4 years. These findings agree with familial high-risk studies, prospective cohort studies, and retrospective studies showing that schizophrenia is preceded by premorbid neurobehavioural alterations. 2 The aim of the study by Riglin and colleagues1 is to highlight that some of these heterogeneous phenotypic manifestations might index genetic liability for schizophrenia. However, the authors clearly noted that these impairments represent a genetic liability rather than an illness prodrome, and further studies are needed to distinguish early manifestations of liability that reflect pleiotropy from those that represent developmental impairments causally associated with schizophrenia. Empirical knowledge on genetic risk of schizophrenia is rapidly expanding, but many gaps limit our ability to use genetic data to predict future psychosis. Several interacting individual and environmental risk or protective
影响因子：
64.3
作者：
Riglin, Lucy;Collishaw, Stephan;Thapar, Anita
通讯作者：
Thapar, Anita