Automatic calibration of the inlet pressure sensor for the implantable continuous-flow ventricular assist device
Automatic calibration of the inlet pressure sensor for the implantable continuous-flow ventricular assist device
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DOI：
10.1007/s10047-011-0556-x
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发表时间：
2011-03
影响因子：
1.3
通讯作者：
Wei Shi;I. Saito;T. Isoyama;H. Nakagawa;Y. Inoue;T. Ono;A. Kouno;K. Imachi;Y. Abe
中科院分区：
文献类型：
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作者：
Wei Shi;I. Saito;T. Isoyama;H. Nakagawa;Y. Inoue;T. Ono;A. Kouno;K. Imachi;Y. Abe
最近，在使用连续流动血泵的可植入心室辅助装置的开发方面取得了重大进展。然而，控制方法尚未建立。流入插管中的血压（入口压力）是进行充分控制的候选值之一。这也可以提供有关心室吸吮的重要信息。然而，不存在用于入口压力传感器的校准方法。本文提出了一种基于心室抽吸条件下压力波形的进气压力传感器自动校准算法。校准算法是基于胸内压可以代替大气压力的考虑构建的，因为肺对空气开放。我们假设，在吸吮的释放点的入口压力将代表胸内压，因为心房压力将是低的，由于吸吮条件。为了验证校准算法的有效性，我们设计了一个模拟循环系统，可以再现心室吸吮过程。校准算法运行良好，在模拟循环系统中3分钟测量的最大SD为2.1 mmHg。虽然对于精密校准来说偏差稍大，但作为原始校准仍然有用。呼吸变化和其他因素的影响以及校准值的可靠性应通过动物实验作为下一步进行研究。
Significant progress in the development of implantable ventricular assist devices using continuous-flow blood pumps has been made recently. However, a control method has not been established. The blood pressure in the inflow cannula (inlet pressure) is one of the candidates for performing an adequate control. This could also provide important information about ventricle sucking. However, no calibration method for an inlet pressure sensor exists. In this study, an automatic calibration algorithm of the inlet pressure sensor from the pressure waveform at the condition of ventricle sucking was proposed. The calibration algorithm was constructed based on the consideration that intrathoracic pressure could be substituted for atmospheric pressure because the lung is open to air. We assumed that the inlet pressure at the releasing point of the sucking would represent the intrathoracic pressure, because the atrial pressure would be low owing to the sucking condition. A special mock circulation system that can reproduce ventricle sucking was developed to validate the calibration algorithm. The calibration algorithm worked well with a maximum SD of 2.1 mmHg for 3-min measurement in the mock circulation system. While the deviation was slightly large for an elaborate calibration, it would still be useful as a primitive calibration. The influence of the respiratory change and other factors as well as the reliability of the calibration value should be investigated with an animal experiment as a next step.