New enone derivatives of oleanolic acid and ursolic acid as inhibitors of nitric oxide production in mouse macrophages
New enone derivatives of oleanolic acid and ursolic acid as inhibitors of nitric oxide production in mouse macrophages
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DOI：
10.1016/s0960-894x(97)00279-5
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发表时间：
1997-07-08
影响因子：
2.7
通讯作者：
Sporn, MB
中科院分区：
文献类型：
--
作者：
Honda, T;Finlay, HJ;Sporn, MB
合成了3-氧代-1-烯-28-酸和3-氧代-1-烯-28-酸的新衍生物。当在1 μ M水平下测定时，其中9个对干扰素-γ诱导的小鼠巨噬细胞中一氧化氮的产生表现出显着的抑制活性。3，12-二氧代-1，9-二烯-28-酸（3）具有最高活性（IC 50，0.9 μ M）。(C)1997年爱思唯尔科学有限公司
New derivatives of 3-oxoolean-1-en-28 oic acid and 3-oxours-1-en-28-oic acid were synthesized. Nine of them showed significant inhibitory activity against interferon-gamma-induced nitric oxide production in mouse macrophages when assayed at the 1 mu M level. 3,12-Dioxoolean-1,9-dien-28-oic acid (3) had the highest activity (IC50, 0.9 mu M). (C) 1997 Elsevier Science Ltd.