Does cardiovascular risk reduction alleviate erectile dysfunction in men with type II diabetes mellitus?
Does cardiovascular risk reduction alleviate erectile dysfunction in men with type II diabetes mellitus?
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DOI：
10.1038/ijir.2008.36
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发表时间：
2008-09-01
影响因子：
2.6
通讯作者：
Wu, W-C
中科院分区：
文献类型：
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作者：
Khatana, S. A. M.;Taveira, T. H.;Wu, W-C
2004年至2007年，41名患有II型糖尿病的退伍军人在普罗维登斯退伍军人事务医学中心接受了为期4周的降低心脏风险的行为和药物干预，并在干预后3个月进行了随访。勃起功能障碍(ED)采用5项国际勃起功能指数(IIEF-5)评定。在干预过程中，参与者在血红蛋白A1c(HbA1c)、舒张压和总胆固醇水平方面经历了显著改善。收缩压和舒张压的变化以及糖化血红蛋白降低或维持在7.0%以下与IIEF-5的变化显著相关(分别为P=0.01，P=0.01，P=0.04)。这些结果表明，改善男性糖尿病患者的血压和血糖控制可能会导致ED的改善。
Veterans (N=41) with type II diabetes were enrolled in a behavioral and pharmacologic intervention for cardiac risk reduction for 4 weeks at the Providence Veterans Affairs Medical Center during 2004-2007 and were followed up 3 months post intervention. Erectile dysfunction (ED) was assessed using the 5-item version of the International Index of Erectile Function (IIEF-5). Participants experienced significant improvements in hemoglobin A1c (HbA1c), diastolic blood pressure and total cholesterol levels over the course of the intervention. Change in systolic and diastolic blood pressure and reduction in or maintenance of HbA1c below 7.0% were significantly associated with change in IIEF-5 (P=0.01, P=0.01, P=0.04, respectively). These results suggest that improved blood pressure and glycemic control in men with diabetes may lead to an improvement in ED.