Prevalence and determinants of elevated apolipoprotein B and dense low-density lipoprotein in youths with type 1 and type 2 diabetes
Prevalence and determinants of elevated apolipoprotein B and dense low-density lipoprotein in youths with type 1 and type 2 diabetes
复制标题
DOI：
10.1210/jc.2007-2176
复制
发表时间：
2008-03-01
影响因子：
5.8
通讯作者：
Dabelea, Dana M.
中科院分区：
文献类型：
--
作者：
Albers, John J.;Marcovina, Santica M.;Dabelea, Dana M.
目的：本研究的目的是评估载脂蛋白B（apoB）和高密度低密度脂蛋白（LDL）在美国1型或2型糖尿病青年中的患病率和决定因素。S.-结果：在1型糖尿病患者中，11%的患者apoB水平升高（>= 100 mg/dl，1.95 mM/L），8%的患者LDL水平升高（相对浮动率= 130 mg/dl，3.36 mM/L）。相比之下，在2型糖尿病患者中，36%的人apoB升高，36%的人有致密LDL，但只有23%的人有LDL胆固醇升高。在两种类型中，致密LDL和apoB均随血红蛋白A1 c增加。在血糖控制不佳的1型糖尿病患者中（血红蛋白A1 c>= 9.5%），28%的患者apoB升高，18%的患者LDL致密化，而控制不良的2型糖尿病患者中72%的患者apoB升高，62%的患者LDL致密化。在1型糖尿病青年中，apoB和高密度LDL升高并不普遍，而apoB升高和高密度LDL是青年2型糖尿病常见的脂蛋白异常。在两组中，这些危险因素的患病率随着血糖控制不良而显著增加，强调了实现和维持最佳血糖控制的重要性。
Objective: The objective of the study was to assess the prevalence and determinants of elevated apolipoprotein B ( apoB) and dense low-density lipoprotein (LDL) in United States youth with type 1 or type 2 diabetes.Methods: We conducted cross-sectional analyses of apoB concentrations, LDL density, and prevalence of elevated apoB levels and dense LDL from the SEARCH for Diabetes in Youth study, a six-center U. S.-based study of youth with diabetes onset younger than 20 years of age ( 2657 with type 1 and 345 with type 2).Results: Among youth with type 1 diabetes, 11% had elevated apoB ( >= 100 mg/dl, 1.95 mM/liter), 8% had dense LDL ( relative flotation rate = 130 mg/dl, 3.36 mM/liter). In contrast, among youth with type 2 diabetes, 36% had elevated apoB, 36% had dense LDL, but only 23% had elevated LDL-cholesterol. Dense LDL and apoB each increased with hemoglobin A1c in both types. Among type 1 diabetics in poor glycemic control ( hemoglobin A1c >= 9.5%), 28% had elevated apoB, and 18% had dense LDL, whereas 72% of poorly controlled type 2 diabetics had elevated apoB and 62% had dense LDL.Conclusions: In youth with type 1 diabetes, elevated apoB and dense LDL were not highly prevalent, whereas elevated apoB and dense LDL were common lipoprotein abnormalities in youth with type 2 diabetes. The prevalence of these risk factors substantially increased with poor glycemic control in both groups, stressing the importance of achieving and maintaining an optimal glucose control.