Effects of ethanol exposure during the third trimester equivalent on neuron number in rat hippocampus and dentate gyrus.
Effects of ethanol exposure during the third trimester equivalent on neuron number in rat hippocampus and dentate gyrus.
复制标题
妊娠晚期乙醇暴露对大鼠海马和齿状回神经元数量的影响。
DOI：
10.1111/j.1530-0277.1986.tb05070.x
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Cassell,MD
中科院分区：
文献类型：
--
作者：
West,JR;Hamre,KM;Cassell,MD
在出生后第4天至第10天，使用人工饲养程序将新生大鼠暴露于含有3.74%乙醇的配方。该处理产生的平均血液乙醇浓度为379.8 ± 17.3 mg/dl。当幼仔在出生后第10天下午被套上时，与单次和成对喂养的对照组相比，乙醇暴露大鼠的脑重/体重比分别降低了22.4%和21.5%。与对照组相比，乙醇暴露也导致海马CA 4区神经元减少16%，但在CA 1或CAS区没有产生缺陷。齿状回的颗粒cefl层中的神经元数量也增加了10%（暴露时处于增殖期的ceto群体）。乙醇暴露并没有影响ceN的大小在任何四个神经元群体测量。这些结果表明，在检查的剂量和时间参数内，在妊娠晚期等同的乙醇暴露似乎优先对发育中的神经元的特定群体有害。
An artificial rearing procedure was used to expose neonatal rats to a formula containing 3.74% ethanol during postnatal days 4 through 10. This treatment produced a mean blood ethanol concentration of 379.8 ± 17.3 mg/dl. When the pups were kitted on the afternoon of postnatal day 10, brain weight to body weight ratio in the ethanol‐exposed rats was reduced 22.4% and 21.5% compared to suckle and pair‐fed controls, respectively. Ethanol exposure also resulted in a 16% reduction of neurons in hippocampal field CA4, compared to controls, but did not produce deficits in fields CA1 or CAS. There was also a 10% increase in the number of neurons (a population of ceto in the midst of a proliferative phase at the time of the exposure) in the granule cefl layer of the dentate gyrus. The ethanol exposure did not affect ceN size in any of the four neuron populations measured. These results suggest, that within the dose and timing parameters examined, ethanol exposure during the third trimester equivalent appears to be preferentially harmful to specific populations of developing neurons.