Near nerve local insulin prevents conduction slowing in experimental diabetes
Near nerve local insulin prevents conduction slowing in experimental diabetes
复制标题
近神经局部胰岛素可防止实验性糖尿病中的传导减慢
DOI：
10.1016/s0006-8993(97)00412-5
复制
发表时间：
1997
期刊：
影响因子：
2.9
通讯作者：
D. Zochodne
中科院分区：
文献类型：
--
作者：
Ashutosh Singhal;Chu Cheng;Hong Sun;D. Zochodne
胰岛素可能通过其对胰岛素受体的作用或通过胰岛素样生长因子-1受体的交叉占据对轴突产生直接作用。我们测试了胰岛素本身影响有髓纤维传导的假设，独立于实验性糖尿病的高血糖。低剂量间歇性（0.2单位，每周三次）多伦多（常规）胰岛素注射在坐骨切迹和膝关节左侧坐骨神经附近的大鼠与柠檬酸盐缓冲链脲佐菌素或非糖尿病大鼠给予柠檬酸盐。在对侧右侧坐骨神经附近注射等体积的生理盐水。糖尿病大鼠出现高血糖，糖化血红蛋白水平升高，右侧（生理盐水处理）坐骨胫骨运动和尾部感觉传导速度减慢。相反，左侧局部胰岛素治疗防止了传导减慢，单侧增加了传导速度。在非糖尿病大鼠中，胰岛素治疗侧的传导速度略高，但胰岛素的影响不如糖尿病患者强。糖尿病患者经胰岛素处理的坐骨神经腓肠神经支中直径≤9.0 μm的有髓小纤维所占百分比高于生理盐水处理的神经。局部胰岛素对有髓纤维具有营养作用，这在糖尿病神经中是突出的，并且与高血糖无关。
Insulin may have direct effects on axons through its actions on insulin receptors or through cross occupancy of insulin-like growth factor-1 receptors. We tested the hypothesis that insulin itself influences conduction of myelinated fibers independent of hyperglycemia in experimental diabetes. Low dose intermittent (0.2 units thrice weekly) Toronto (regular) insulin was injected at the sciatic notch and knee near the left sciatic nerve of rats rendered diabetic with citrate buffered streptozotocin or nondiabetic rats given citrate only. Identical volumes of normal saline were injected near the contralateral right sciatic nerve. The diabetic rats developed hyperglycemia, elevated glycosylated hemoglobin levels and had slowing of right (saline treated) sciatic tibial motor and caudal sensory conduction velocity. In contrast, local insulin treatment on the left side prevented conduction slowing, unilaterally increasing conduction velocity. In nondiabetic rats, conduction velocities were slightly higher on the insulin treated side, but the influence of insulin was less robust than in diabetics. The insulin treated sural branches of the sciatic nerves in diabetics had a higher percentage of small (≤9.0 μm diameter) myelinated fibers than the saline treated nerves. Local insulin has a trophic influence on myelinated fibers that is prominent in diabetic nerves and is independent of hyperglycemia.
影响因子：
14.5
作者：
TUCK, RR;SCHMELZER, JD;LOW, PA
通讯作者：
LOW, PA
影响因子：
--
作者：
CAMERON, NE;COTTER, MA;LOW, PA
通讯作者：
LOW, PA