Innate immunity: the first line of defense against SARS-CoV-2.
Innate immunity: the first line of defense against SARS-CoV-2.
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DOI：
10.1038/s41590-021-01091-0
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发表时间：
2022-03
影响因子：
30.5
通讯作者：
Kanneganti TD
中科院分区：
文献类型：
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作者：
Diamond MS;Kanneganti TD
由SARS-CoV-2引起的冠状病毒病2019年(新冠肺炎)大流行继续造成大量发病率和死亡率。虽然大多数感染是轻微的，但一些患者经历了严重的、可能致命的全身炎症、组织损伤、细胞因子风暴和急性呼吸窘迫综合征。先天免疫系统充当第一道防线，通过模式识别受体感知病毒，并激活促进病毒清除的炎症途径。在这里，我们讨论参与病毒识别和由此产生的炎症的先天免疫过程，以及这一见解如何使针对新冠肺炎的治疗干预措施的开发成为可能。更好地了解先天免疫系统如何检测和应对SARS-CoV-2将有助于确定减轻严重疾病和改善患者预后的有针对性的治疗方式。
The coronavirus disease 2019 (COVID-19) pandemic, caused by SARS-CoV-2, continues to cause substantial morbidity and mortality. While most infections are mild, some patients experience severe and potentially fatal systemic inflammation, tissue damage, cytokine storm and acute respiratory distress syndrome. The innate immune system acts as the first line of defense, sensing the virus through pattern recognition receptors and activating inflammatory pathways that promote viral clearance. Here, we discuss the innate immune processes involved in virus recognition and the resultant inflammation, and how this insight has enabled the development of therapeutic interventions against COVID-19. An improved understanding of how the innate immune system detects and responds to SARS-CoV-2 will help identify targeted therapeutic modalities that mitigate severe disease and improve patient outcomes.