Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020.
Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020.
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DOI：
10.1016/j.lanepe.2021.100075
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Ladhani SN
中科院分区：
文献类型：
--
作者：
Flood J;Shingleton J;Bennett E;Walker B;Amin-Chowdhury Z;Oligbu G;Avis J;Lynn RM;Davis P;Bharucha T;Pain CE;Jyothish D;Whittaker E;Dwarakanathan B;Wood R;Williams C;Swann O;Semple MG;Ramsay ME;Jones CE;Ramanan AV;Gent N;Ladhani SN
2020年4月首次发现的与SARS-CoV-2暂时相关的儿科多系统炎症综合征（PIMS-TS）具有川崎（KD）和中毒性休克综合征（TSS）的共同特征。监测描述了PIMS-TS在英国和爱尔兰的流行病学和临床特征。英国公共卫生部通过英国儿科监测单位启动了对PIMS-TS的前瞻性国家监测。每月联系儿科医生，以电子方式报告PIMS-TS、KD和TSS病例，并填写详细的临床问卷。纳入了2020年3月1日至6月15日期间出现症状的病例。有216例仅具有PIMS-TS特征，13例具有PIMS-TS和KD特征，28例具有PIMS-TS和TSS特征，11例具有PIMS-TS、KD和TSS特征，表型组之间的年龄、种族、临床表现和疾病严重程度存在差异。SARS-CoV-2感染率和PIMS-TS病例之间存在很强的地理和时间关联。其中，14.8%（39/264）的儿童有SARS-CoV-2 RT-PCR阳性，63.6%（75/118）的SARS-CoV-2抗体阳性。总共有44.0%（118/268）需要重症监护，这在TSS表型病例中更常见。5例心脏骤停患儿中3例有TSS表型。三名儿童（1.1%）死亡。SARS-CoV-2感染和PIMS-TS之间的密切联系强调了保持低社区感染率以降低儿童和青少年这种罕见但严重的并发症风险的重要性。密切随访对监测PIMS-TS患儿的长期并发症非常重要。
Paediatric Multisystem Inflammatory Syndrome temporally associated with SARS-CoV-2 (PIMS-TS), first identified in April 2020, shares features of both Kawasaki disease (KD) and toxic shock syndrome (TSS). The surveillance describes the epidemiology and clinical characteristics of PIMS-TS in the United Kingdom and Ireland. Public Health England initiated prospective national surveillance of PIMS-TS through the British Paediatric Surveillance Unit. Paediatricians were contacted monthly to report PIMS-TS, KD and TSS cases electronically and complete a detailed clinical questionnaire. Cases with symptom onset between 01 March and 15 June 2020 were included. There were 216 cases with features of PIMS-TS alone, 13 with features of both PIMS-TS and KD, 28 with features of PIMS-TS and TSS and 11 with features of PIMS-TS, KD and TSS, with differences in age, ethnicity, clinical presentation and disease severity between the phenotypic groups. There was a strong geographical and temporal association between SARS-CoV-2 infection rates and PIMS-TS cases. Of those tested, 14.8% (39/264) children had a positive SARS-CoV-2 RT-PCR, and 63.6% (75/118) were positive for SARS-CoV-2 antibodies. In total 44·0% (118/268) required intensive care, which was more common in cases with a TSS phenotype. Three of five children with cardiac arrest had TSS phenotype. Three children (1·1%) died. The strong association between SARS-CoV-2 infection and PIMS-TS emphasises the importance of maintaining low community infection rates to reduce the risk of this rare but severe complication in children and adolescents. Close follow-up will be important to monitor long-term complications in children with PIMS-TS.
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影响因子：
2.3
作者：
Jain S;Sen S;Lakshmivenkateshiah S;Bobhate P;Venkatesh S;Udani S;Shobhavat L;Andankar P;Karande T;Kulkarni S
通讯作者：
Kulkarni S
DOI：
10.1038/s41584-020-00566-y
发表时间：
2021-03
期刊：
Nature reviews. Rheumatology
影响因子：
--
作者：
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通讯作者：
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影响因子：
27.4
作者：
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通讯作者：
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影响因子：
8.4
作者：
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通讯作者：
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影响因子：
33.9
作者：
Godfred-Cato, Shana;Bryant, Bobbi;Belay, Ermias
通讯作者：
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