Early renal denervation prevents development of hypertension in growth-restricted offspring.
Early renal denervation prevents development of hypertension in growth-restricted offspring.
复制标题
早期肾去神经术可防止生长受限的后代发生高血压。
DOI：
10.1111/j.1440-1681.2007.04754.x
复制
发表时间：
2007
影响因子：
2.9
通讯作者：
Alexander,BarbaraT
中科院分区：
文献类型：
--
作者：
Ojeda,NormaB;Johnson,WRussell;Dwyer,TerryM;Alexander,BarbaraT
1Low birth weight is associated with an increased risk for the development of hypertension. Our laboratory uses a model of reduced uterine perfusion in the pregnant rat that results in intrauterine growth‐restricted (IUGR) offspring that develop hypertension at a prepubertal age. Although hypertension develops in both prepubertal male and female IUGR offspring, only male IUGR offspring remain hypertensive after puberty. We reported previously that bilateral renal denervation abolishes hypertension in adult male IUGR offspring, indicating an important role for the renal nerves in the maintenance of established IUGR‐induced hypertension. We also reported that angiotensin‐converting enzyme inhibition abolishes hypertension in adult male IUGR offspring. However, activation of the renin–angiotensin system does not occur in male IUGR offspring until after puberty, or after the development of established IUGR‐induced hypertension. Therefore, the mechanisms involved in the development of IUGR‐induced hypertension may differ from those involved in the maintenance of established IUGR‐induced hypertension. Thus, the purpose of the present study was to determine whether the renal nerves play a causative role in the early development of IUGR‐induced hypertension in prepubertal IUGR offspring.2Intrauterine growth‐restricted and control offspring were subjected to either bilateral renal denervation or sham denervation, respectively, at 4 weeks of age. Mean arterial pressure (MAP) was determined at 6 weeks of age in conscious, chronically instrumented animals. Adequacy of renal denervation was verified by renal noradrenaline content.3Whereas renal denervation had no effect on MAP in control offspring (103 ± 2vs102 ± 3 mmHg for shamvsdenervated, respectively), it reduced blood pressure in growth‐restricted offspring (114 ± 3vs104 ± 1 mmHg for shamvsdenervated, respectively;P< 0.01). Renal noradrenaline content was significantly reduced in denervated animals relative to sham operated rats.4Thus, the data indicate a role for the renal nerves in the aetiology of IUGR‐induced hypertension and suggest that the renal nerves may participate in the early development of hypertension in IUGR offspring in addition to established hypertension observed in adult male IUGR offspring.
