Relationship of platelet MAO activity to characteristics of major depressive illness.
Relationship of platelet MAO activity to characteristics of major depressive illness.
复制标题
血小板 MAO 活性与重度抑郁症特征的关系。
DOI：
10.1016/0165-1781(86)90118-6
复制
发表时间：
1986
影响因子：
11.3
通讯作者：
Stokes,PE
中科院分区：
文献类型：
--
作者：
Georgotas,A;McCue,RE;Friedman,E;Hapworth,WE;Kim,OM;Cooper,TB;Chang,I;Stokes,PE
67名患有重度抑郁症的患者（小于55岁）进行了血小板单胺氧化酶（MAO）活性的预处理测定。与之前的研究一样，女性的MAO活性高于男性，并且MAO活性与年龄呈正相关。忧郁症患者（DSM-III）的MAO活性明显高于无忧郁症患者。这一发现可能反映了较高的MAO活性与快感缺乏和情绪自主症状有关。焦虑也与较高的MAO活性相关，就像积极的抑郁家族史一样。此外，地塞米松后皮质醇水平与血小板MAO活性相关。
Sixty-seven patients (⩾55 years of age) with major depressive disorder had pretreatment assays of platelet monoamine oxidase (MAO) activity. As in previous studies, women had higher MAO activity than men, and MAO activity was positively correlated with age. Patients with melancholia (DSM-III) had significantly higher MAO activity than those without melancholia. This finding may reflect the higher MAO activity associated with the symptoms of anhedonia and mood autonomy. Anxiety also was correlated with higher MAO activity, as was a positive family history of depression. In addition, postdexamethasone cortisol levels were correlated with platelet MAO activity.