Distinct basal ganglia territories are engaged in early and advanced motor sequence learning
Distinct basal ganglia territories are engaged in early and advanced motor sequence learning
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DOI：
10.1073/pnas.0502762102
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发表时间：
2005-08-30
影响因子：
11.1
通讯作者：
Doyon, J
中科院分区：
文献类型：
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作者：
Lehéricy, S;Benali, H;Doyon, J
在这项研究中，我们使用高场（3 T）的功能性MRI（fMRI）来跟踪整个基底神经节回路以及其他运动相关结构的激活时间过程，在一个月的训练中，明确学习一系列手指运动。14名右利手的健康志愿者每天练习15分钟，用左手做8个动作。在第1、14和28天进行MRI检查。在这两个壳核，激活减少与实践中rostrodoral（联合）地区。与此相反，有一个显着的信号增加，在更多的尾腹（感觉运动）地区的壳核。随后的信号变化和行为变量之间的相关性分析表明，错误率（运动准确性）与早期学习期间激活的区域中的信号变化呈正相关，而反应时间（运动速度）与高级学习阶段激活的区域中的信号变化呈负相关，包括感觉运动壳核和苍白球。这些结果表明，在明确的运动序列的学习过程中，运动表征从纹状体-苍白球复合体的感觉运动领域的关联转移的可能性，这表明运动技能存储在基底神经节的感觉运动领域，支持快速的性能。
In this study, we used functional MRI (fMRI) at high field (3T) to track the time course of activation in the entire basal ganglia circuitry, as well as other motor-related structures, during the explicit learning of a sequence of finger movements over a month of training. Fourteen right-handed healthy volunteers had to practice 15 min daily a sequence of eight moves using the left hand. MRI sessions were performed on days 1, 14 and 28. In both putamen, activation decreased with practice in rostrodorsal (associative) regions. In contrast, there was a significant signal increase in more caudoventral (sensorimotor) regions of the putamen. Subsequent correlation analyses between signal variations and behavioral variables showed that the error rate (movement accuracy) was positively correlated with signal changes in areas activated during early learning, whereas reaction time (movement speed) was negatively correlated with signal changes in areas activated during advanced learning stages, including the sensorimotor putamen and globus pallidus. These results suggest the possibility that motor representations shift from the associative to the sensorimotor territories of the striato-pallidal complex during the explicit learning of motor sequences, suggesting that motor skills are stored in the sensorimotor territory of the basal ganglia that supports a speedy performance.