Terahertz biosensing with a graphene-metamaterial heterostructure platform
Terahertz biosensing with a graphene-metamaterial heterostructure platform
复制标题
使用石墨烯超材料异质结构平台进行太赫兹生物传感
DOI：
10.1016/j.carbon.2018.09.050
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发表时间：
2019-01-01
期刊：
影响因子：
10.9
通讯作者：
Ying, Yibin
中科院分区：
文献类型：
--
作者：
Xu, Wendao;Xie, Lijuan;Ying, Yibin
太赫兹（THz）辐射引起了材料表征、无损安全筛查、临床诊断以及化学品和分子识别等领域的极大兴趣。对包括生物分子在内的痕量目标进行无标记太赫兹传感是有前途的，因为它们在该电磁区域具有丰富的光谱指纹；然而，提高灵敏度仍然是一个挑战，部分原因是太赫兹源和探测器的限制。尽管超材料表面的生物传感仍然需要高度复杂的装饰工艺，但超材料和超表面中的共振增强电磁场提供了一种潜在可行的解决方案。在这里，我们通过将单层石墨烯集成在太赫兹超材料吸收腔上来演示一个简单的生物传感平台，其中传感目标的引入由于与石墨烯的强烈相互作用而导致超材料共振吸收（或反射）的巨大变化。我们通过检测低至 0.2 ng 的痕量甲基毒死蜱，通过实验证明了其超高灵敏度。使用简单的修饰步骤并利用 DNA 捕获凝血酶，我们进一步展示了该平台作为敏感生物传感器的可行性。 (C) 2018 年由爱思唯尔有限公司出版。
Terahertz (THz) radiation attracted great interest in the fields of material characterization, nondestructive security screening, clinical diagnostics, and identification of chemicals and molecules. Label-free THz sensing of trace amount of targets including biomolecules is promising because of their rich spectral fingerprint in this electromagnetic region; however, improving the sensitivity remains to be a challenge, partially due to the limitations of THz sources and detectors. The resonantly enhanced electromagnetic fields in metamaterials and metasurfaces offer a potentially viable solution, although highly complicated decoration process is still needed for biosensing on the surface of metamaterials. Here we demonstrate a simple biosensing platform by integrating a monolayer graphene on a THz metamaterial absorber cavity, where the introduction of sensing targets results in a large change of the metamaterial resonant absorption (or reflection) because of their strong interaction with graphene. We experimentally show its ultrahigh sensitivity through detecting trace amount of chlorpyrifos methyl down to 0.2 ng. Using simple decoration steps and utilizing DNA to capture thrombin, we further show the feasibility of this platform serving as a sensitive biosensor. (C) 2018 Published by Elsevier Ltd.