Habitual coffee intake reduces all-cause mortality by decreasing heart rate
Habitual coffee intake reduces all-cause mortality by decreasing heart rate
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DOI：
10.1007/s00380-019-01422-0
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发表时间：
2019-05
影响因子：
1.5
通讯作者：
Yume Nohara-Shitama;H. Adachi;M. Enomoto;A. Fukami;S. Nakamura;Shoko Kono;N. Morikawa;A. Sakaue-
中科院分区：
文献类型：
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作者：
Yume Nohara-Shitama;H. Adachi;M. Enomoto;A. Fukami;S. Nakamura;Shoko Kono;N. Morikawa;A. Sakaue-
众所周知，代谢综合征患者的静息心率升高。我们之前报道过心率升高与全因死亡率显著相关，而咖啡摄入与代谢综合征呈负相关。我们假设喝更多的咖啡可以通过降低静息心率来降低全因死亡率。我们在Tanushimaru（七国研究的一个队列）进行了纵向流行病学研究。1999年，共有1920名40岁以上的居民接受了健康检查。我们测量了代谢综合征的组成部分，并通过食物频率问卷评估饮食模式。我们每年对参与者进行随访，持续了15年。在随访期间，343名参与者死亡。其中102人死于癌症，48人死于脑血管疾病，44人死于传染病。多变量分析显示，高咖啡摄入量与静息心率呈负相关。Kaplan-Meier曲线发现，咖啡摄入量高的人群死亡率较低。在咖啡摄入量较低的组中，心率增加的五分之一组的全因死亡风险比升高，而在咖啡摄入量较高的组中，心率与全因死亡无关。在进一步调整混杂因素后，这些显著的关联仍然存在。这项前瞻性研究表明，由于降低静息心率，高咖啡摄入量可能对全因死亡有保护作用。
It is well known that subjects with metabolic syndrome show an elevated resting heart rate. We previously reported that elevated heart rate was significantly related to all-cause mortality, and that coffee consumption was inversely associated with metabolic syndrome. We hypothesized that higher coffee consumption may decrease all-cause mortality by reducing resting heart rate. We performed a longitudinal epidemiological study in Tanushimaru (a cohort of the Seven Countries Study). A total of 1920 residents aged over 40 years received health checkups in 1999. We measured components of metabolic syndrome, and eating and drinking patterns were evaluated by a food frequency questionnaire. We followed up the participants annually for 15 years. During the follow-up period, 343 of the participants died. Of these, 102 subjects died of cancer, 48 of cerebro-cardiovascular diseases, and 44 of infectious diseases. Multivariate analyses revealed that higher coffee consumption was inversely associated with resting heart rate. Kaplan–Meier curves found lower mortality rates in the higher coffee consumption groups. In the lower coffee consumption groups, elevated hazard ratios of all-cause death were observed in the increased heart rate quintiles, whereas heart rate was not associated with all-cause death in the higher coffee consumption groups. These significant associations remained after further adjustment for confounders. This prospective study suggests that higher coffee consumption may have a protective effect against all-cause death due to reducing resting heart rate.