A low-power high-sensitivity single-chip receiver for NMR microscopy
A low-power high-sensitivity single-chip receiver for NMR microscopy
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DOI：
10.1016/j.jmr.2016.03.004
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发表时间：
2016-05-01
影响因子：
2.2
通讯作者：
Boero, Giovanni
中科院分区：
文献类型：
--
作者：
Anders, Jens;Handwerker, Jonas;Boero, Giovanni
在本文中，我们提出了一种采用 0.13 μm CMOS 技术制造的用于 NMR 显微镜应用的完全集成接收器。该设计将 10 匝平面检测线圈与完整的正交低中频下变频接收器共同集成在单个芯片上，该接收器采用 1.5 V 单电源供电，总功耗为 18 mW。该探测器在 7 T 时测得的时域自旋灵敏度为 3 x 10(13) H-1 自旋/根 Hz。此外，本文还讨论了使用平面检测线圈的 NMR 显微镜的两个重要方面：检测线圈的自旋灵敏度和可实现的图像 SNR 之间的联系，以及由平面检测线圈的不均匀灵敏度分布引起的图像伪影的校正。更具体地说，我们推导了作为线圈自旋灵敏度函数的理论图像 SNR 和 CTI MR 成像实验中已知线圈灵敏度分布的灵敏度校正的解析表达式。这两种表达式都使用本文成像部分中的测量数据进行了验证。与之前提出的设计相比，由于所用集成接收器芯片的自旋灵敏度得到了提高，我们能够在 7 T 光谱磁体中获得灵敏度校正图像，各向同性分辨率分别为 9.6 μm 和 5 μm，单次 SNR 分别为 37 和 15，成像时间相对较短，分别为 4.4 小时和 24 小时。 (C) 2016 Elsevier Inc. 保留所有权利。
In this paper, we present a fully-integrated receiver for NMR microscopy applications manufactured in a 0.13 mu m CMOS technology. The design co-integrates a 10-turn planar detection coil together with a complete quadrature, low-IF downconversion receiver on a single chip, which operates from a single 1.5 V supply with a total power dissipation of 18 mW. The detector's measured time-domain spin sensitivity is 3 x 10(13) H-1 spins/root Hz at 7 T. Additionally, the paper discusses two important aspects of NMR microscopy using planar detection coils: the link between the detection coil's spin sensitivity and the achievable image SNR and the correction of image artifacts induced by the inhomogeneous sensitivity profile of planar detection coils. More specifically, we derive analytical expressions for both the theoretical image SNR as a function of the coil's spin sensitivity and the sensitivity correction for a known coil sensitivity profile in CTI MR imaging experiments. Both expressions are validated using measured data in the imaging section of the paper. Thanks to the improved spin sensitivity of the utilized integrated receiver chip compared to a previously presented design, we were able to obtain sensitivity corrected images in a 7 T spectroscopy magnet with isotropic resolutions of 9.6 mu m and 5 mu m with single-shot SNRs of 37 and 15 in relatively short imaging times of 4.4 h and 24 h, respectively. (C) 2016 Elsevier Inc. All rights reserved.