Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 as an Early Biomarker for ST Elevation Myocardial Infarction - Time-Dependent Comparison With Other Biomarkers
Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 as an Early Biomarker for ST Elevation Myocardial Infarction - Time-Dependent Comparison With Other Biomarkers
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DOI：
10.1253/circj.cj-10-0913
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发表时间：
2011-06-01
影响因子：
3.3
通讯作者：
Mizuno, Kyoichi
中科院分区：
文献类型：
--
作者：
Kobayashi, Nobuaki;Hata, Noritake;Mizuno, Kyoichi
背景：心肌坏死标志物，如肌酸激酶- mb （CK-MB）、心肌肌钙蛋白、肌红蛋白和心脏型脂肪酸结合蛋白（H-FABP）对st段抬高型心肌梗死（STEMI）早期诊断的敏感性仍然不足。我们比较了一种新的鼠疫易感性生物标志物（可溶性凝集素样氧化低密度脂蛋白受体-1，sLOX-1）与STEMI早期的其他生物标志物。方法与结果：测定125例STEMI、44例非STEMI （NSTEMI）和125例非急性心肌梗死（non-AMI）患者血浆sLOX-1水平，随访2 h，差异均有统计学意义（P= 2 h）。入院时（发病后89min） sLOX-1、H-FABP、肌红蛋白、肌钙蛋白T和CK-MB对STEMI的诊断敏感性分别为93%、78%、70%、56%和33%。结论：血浆sLOX-1对STEMI早期诊断的准确性高于H-FABP、肌红蛋白、肌钙蛋白T和CK-MB。（Circ J 2011; 75: 1433-1439）
Background: The diagnostic sensitivity of myocardial necrosis markers, such as creatine kinase-MB (CK-MB), cardiac troponins, myoglobin and heart-type fatty acid-binding protein (H-FABP) for the earliest stage of ST-elevation myocardial infarction (STEMI), remains insufficient. We compared a new biomarker of plague vulnerability (soluble lectin-like oxidized low-density lipoprotein receptor-1, sLOX-1) with other biomarkers at the earliest stage of STEMI.Methods and Results: Plasma sLOX-1 levels were measured in 125 STEMI, 44 non-STEMI (NSTEMI) and 125 non-acute myocardial infarction (non-AMI) patients and were significantly (P= 2 h thereafter. The diagnostic sensitivity of sLOX-1, H-FABP, myoglobin, troponin T and CK-MB for STEMI upon admission (89min after onset) was 93%, 78%, 70%, 56% and 33%, respectively.Conclusions: Plasma sLOX-1 diagnosed the early stages of STEMI more accurately than H-FABP, myoglobin, troponin T and CK-MB. (Circ J 2011; 75: 1433-1439)