Gold nanoflowers for 3D volumetric molecular imaging of tumors by photoacoustic tomography
Gold nanoflowers for 3D volumetric molecular imaging of tumors by photoacoustic tomography
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DOI：
10.1007/s12274-014-0688-4
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发表时间：
2015-07
期刊：
影响因子：
9.9
通讯作者：
Yuanyuan Jiang;Z. Deng;Dan Yang;Xin Deng;Qi Li;Yinlin Sha;Changhui Li;Dongsheng Xu
中科院分区：
文献类型：
--
作者：
Yuanyuan Jiang;Z. Deng;Dan Yang;Xin Deng;Qi Li;Yinlin Sha;Changhui Li;Dongsheng Xu
金纳米粒子（AuNPs）通过与靶向肿瘤细胞的分子探针结合，具有上级特性，在肿瘤分子成像研究中显示出巨大的潜力。肿瘤内靶向AuNP的非侵入性、高分辨率和三维成像对于诊断和治疗都是理想的。在这项研究中，金纳米花（AuNFs）作为一种新的造影剂的光声断层扫描（PAT）。通过与分子探针叶酸结合，尾静脉注射的AuNF集中在小鼠的肿瘤部位内;这通过三维（3D）PAT成像清楚地可视化。此外，毒性试验证明AuNFs对活细胞和动物无害。我们的研究结果表明，金纳米纤维在肿瘤分子成像中具有巨大的潜力。
By binding molecular probes that target tumor cells, gold nanoparticles (AuNPs) with superior characteristics have shown great potential in tumor molecular imaging studies. The non-invasive, high-resolution, and three-dimensional imaging of the targeted AuNPs within the tumor is desirable for both diagnosis and therapy. In this study, gold nanoflowers (AuNFs) are presented as a novel contrast agent for photoacoustic tomography (PAT). By binding to folic acid, the molecular probe, the tail-vein injected AuNFs concentrated within the tumor site in mice; this was clearly visualized by three-dimensional (3D) PAT imaging. In addition, toxicity assay proved that AuNFs were harmless to living cells and animals. Our results demonstrate that AuNFs have great potential in tumor molecular imaging.