Nerve anastomoses with human fibrin. Preliminary clinical report (56 cases).
Nerve anastomoses with human fibrin. Preliminary clinical report (56 cases).
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DOI：
10.1016/s0753-9053(83)80087-8
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
Narakas, A
中科院分区：
文献类型：
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作者：
Egloff, D V;Narakas, A
自1980年以来，已经用纤维蛋白进行了56次周围神经修复。由于技术原因，臂丛神经修复术中选择了联合修复（23例），大多数其他病例仅使用纤维蛋白（8例游离皮瓣，17例主干，8例指神经）。总的来说，结果与使用缝线的所谓经典修复方法相媲美。粘合剂方法的主要优点是手术时间的增加，而不影响精度。可以实现次要益处，例如止血和更容易稳定小移植物。还有一个问题：纤维蛋白会变成什么？对目前病例的调查倾向于证明，通过第二次吻合的轴突生长与移植物的长度成比例地受到阻碍。纤维蛋白在导致横膈膜硬化的改变过程中的可能作用至今尚未阐明。为进一步完善这种新的神经修复方法，还需进行实验和临床研究。
Since 1980, 56 peripheral nerve repairs have been done with fibrin. For technical reasons, combined anastomoses have been chosen in brachial plexus repairs (23 cases), fibrin alone being used in most other cases (8 free flaps, 17 main trunks, 8 digital nerves). As a whole, results compare evenly with the so-called classical repair methods using stitches. The adhesive method's main advantage is the gain in operative time, without impairing precision. Secondary benefits, such as hemostasis and easier stabilization of small grafts, can be achieved. One question remains: what becomes of fibrin? The survey of present cases would tend to prove that axonal growth through the second anastomosis is impeded proportionally to the length of the graft. The possible action of fibrin in the alteration process leading to a sclerotic diaphragm is not elucidated to this day. Experimental as well as clinical research must be carried on, in order to improve this new way of repairing nerves.