Trifunctional organocatalyst-promoted counterion catalysis for fast and enantioselective aza-Morita-Baylis-Hillman reactions at ambient temperature.
Trifunctional organocatalyst-promoted counterion catalysis for fast and enantioselective aza-Morita-Baylis-Hillman reactions at ambient temperature.
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三官能有机催化剂促进的抗衡离子催化，可在环境温度下实现快速和对映选择性氮杂-森田-贝利斯-希尔曼反应。
DOI：
10.1039/b901781j
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发表时间：
2009
影响因子：
3.2
通讯作者：
Fei Liu
中科院分区：
文献类型：
--
作者：
J. Garnier;Fei Liu
使用三官能有机催化剂促进的不对称抗衡离子定向催化，在环境温度下实现了缺电子或富电子芳香族 N-甲苯磺酰亚胺和甲基乙烯基酮之间的快速和对映选择性氮杂-Morita-Baylis-Hillman 反应，以布朗斯台德碱作为苯甲酸质子化后的活性开关。
Fast and enantioselective aza-Morita-Baylis-Hillman reactions between electron-deficient or electron-rich aromatic N-tosyl imines and methyl vinyl ketone were achieved at ambient temperature using asymmetric counterion-directed catalysis promoted by trifunctional organocatalysts with a Brønsted base as the activity switch after protonation with benzoic acid.