Reactive Oxygen Species in Metabolic and Inflammatory Signaling.
Reactive Oxygen Species in Metabolic and Inflammatory Signaling.
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DOI：
10.1161/circresaha.117.311401
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发表时间：
2018-03-16
影响因子：
20.1
通讯作者：
Griendling KK
中科院分区：
文献类型：
--
作者：
Forrester SJ;Kikuchi DS;Hernandes MS;Xu Q;Griendling KK
活性氧（reactive oxygen species，ROS）在生理和病理信号转导中起重要作用。通常产生ROS的酶和亚细胞区室与代谢调节相关，与代谢功能障碍相关的疾病可能受到氧化还原平衡变化的影响。在这篇综述中，我们总结了目前的文献围绕ROS及其在代谢和炎症调节中的作用，重点是ROS信号转导及其与疾病进展的关系。特别是，我们研究了ROS的生产，如细胞质，线粒体，过氧化物酶体和内质网的隔间，并讨论如何ROS影响代谢过程，如蛋白酶体功能，自噬和一般炎症信号。本文还对ROS在动脉粥样硬化、糖尿病、脑卒中等代谢/炎症性疾病中的调节作用进行了综述。为了成功开发靶向氧化信号传导的改进疗法，了解ROS信号传导在生理学和病理生理学中的平衡以及这种平衡的操纵和ROS的身份如何影响细胞和组织的稳态是至关重要的。增加对ROS产生的特定来源的理解以及对ROS如何影响细胞代谢的理解可能有助于指导我们治疗心血管疾病。
Reactive oxygen species (ROS) are well known for their role in mediating both physiological and pathophysiological signal transduction. Enzymes and subcellular compartments that typically produce ROS are associated with metabolic regulation, and diseases associated with metabolic dysfunction may be influenced by changes in redox balance. In this review, we summarize the current literature surrounding ROS and their role in metabolic and inflammatory regulation, focusing on ROS signal transduction and its relationship to disease progression. In particular, we examine ROS production in compartments such as the cytoplasm, mitochondria, peroxisome and endoplasmic reticulum, and discuss how ROS influence metabolic processes such as proteasome function, autophagy and general inflammatory signaling. We also summarize and highlight the role of ROS in the regulation metabolic/inflammatory diseases including atherosclerosis, diabetes and stroke. To successfully develop improved therapies that target oxidative signaling, it is vital to understand the balance ROS signaling plays in both physiology and pathophysiology, and how manipulation of this balance and the identity of the ROS may influence cellular and tissue homeostasis. An increased understanding of specific sources of ROS production and an appreciation for how ROS influence cellular metabolism may help guide us in this effort to treat cardiovascular diseases.