On the relationship between head circumference, brain size, prenatal long-chain PUFA/5-methyltetrahydrofolate supplementation and cognitive abilities during childhood.
On the relationship between head circumference, brain size, prenatal long-chain PUFA/5-methyltetrahydrofolate supplementation and cognitive abilities during childhood.
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DOI：
10.1017/s0007114516004281
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发表时间：
2019-09-01
期刊：
影响因子：
--
通讯作者：
Campoy, Cristina
中科院分区：
文献类型：
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作者：
Catena, Andres;Martinez-Zaldivar, Cristina;Campoy, Cristina
据报道，婴儿的头围可以预测大脑的大小，总灰质体积（GMV）和神经认知发育。然而，目前尚不清楚它是否对区域和皮层下脑容量有预测价值。我们的目的是探讨几个头围测量出生后的GMV和皮质下体积在儿童后期的分布之间的关系。我们检查了74名白人单胎足月出生的婴儿，其母亲随机接受鱼油和/或5-甲基四氢叶酸或安慰剂产前补充剂。我们评估了出生时、4岁和10岁时的头围，以及7岁时的认知能力。我们在10岁时获得脑MRI，在此基础上进行基于体素的形态测量、皮质表面提取和皮质下分割。分析控制了性别、年龄、身高、体重、家庭状况、偏侧性和总颅内体积。产前补充不会影响任何年龄的头围、认知能力或总脑容量。4岁时的头围与总GMV、白色物质体积和脑表面积的相关性最高，与额、颞、枕区的GMV以及尾状核、苍白球、壳核和丘脑体积也密切相关。随着儿童期脑容量与几种结果之间的关系延伸到成年期，我们发现0至4岁是大脑生长的最佳时间;出生后因素可能对某些皮质区域和皮质下核团的结构成熟产生最相关的影响，而不依赖于产前补充。
Head circumference in infants has been reported to predict brain size, total grey matter volume (GMV) and neurocognitive development. However, it is unknown whether it has predictive value on regional and subcortical brain volumes. We aimed to explore the relationship between several head circumference measurements since birth and distributions of GMV and subcortical volumes at later childhood. We examined seventy-four, Caucasian, singleton, term-born infants born to mothers randomised to receive fish oil and/or 5-methyltetrahydrofolate or placebo prenatal supplementation. We assessed head circumference at birth and at 4 and 10 years of age and cognitive abilities at 7 years of age. We obtained brain MRI at 10 years of age, on which we performed voxel-based morphometry, cortical surface extraction and subcortical segmentation. Analyses were controlled for sex, age, height, weight, family status, laterality and total intracranial volume. Prenatal supplementation did not affect head circumference at any age, cognitive abilities or total brain volumes. Head circumference at 4 years presented the highest correlation with total GMV, white matter volume and brain surface area, and was also strongly associated with GMV of frontal, temporal and occipital areas, as well as with caudate nucleus, globus pallidus, putamen and thalamus volumes. As relationships between brain volumes in childhood and several outcomes extend into adulthood, we have found that ages between 0 and 4 years as the optimal time for brain growth; postnatal factors might have the most relevant impact on structural maturation of certain cortical areas and subcortical nuclei, independent of prenatal supplementation.