Harnessing Surface-Functionalized Metal-Organic Frameworks for Selective Tumor Cell Capture
Harnessing Surface-Functionalized Metal-Organic Frameworks for Selective Tumor Cell Capture
复制标题
利用表面功能化金属有机框架选择性捕获肿瘤细胞
DOI：
10.1021/acs.chemmater.7b03269
复制
发表时间：
2017-10-10
影响因子：
8.6
通讯作者：
Liu, Huwei
中科院分区：
文献类型：
--
作者：
Qi, Xiaoyue;Chang, Ziyong;Liu, Huwei
A platform based on a metal-organic framework (MOF) bearing free carboxylic acid groups has been developed for tumor cell capture and potential drug screening applications. A zinc-based MOF expressing uncoordinated carboxylic acids (ZnMOF-COOH) was grown on a ZnO substrate. Post-synthetic modification (PSM) of the acid groups gave a composite material that expressed peptide linkages and allowed the immobilization of anti-epithelial cell adhesion molecule (anti-EpCAM) antibody. This strategy offers a universal method for the controllable immobilization of antibodies and even enzymes on the surface of a MOF. The resulting immunotrapper exhibited excellent capture ability, demonstrating high efficiency and selectivity towards EpCAM-positive tumor cells. The promotion of tumor cell adhesion is attributed to the 3-dimentional (3D) structure of the composite, which revealed spine-like microstructures.
