Fabrication and characterization of biodegradable KH560 crosslinked chitin hydrogels with high toughness and good biocompatibility
Fabrication and characterization of biodegradable KH560 crosslinked chitin hydrogels with high toughness and good biocompatibility
复制标题
高韧性、生物相容性好的可生物降解KH560交联甲壳素水凝胶的制备及表征
DOI：
10.1016/j.carbpol.2021.117707
复制
发表时间：
2021-02-09
影响因子：
11.2
通讯作者：
Ye, Qifa
中科院分区：
文献类型：
--
作者：
Chen, Biao;Wu, Shuangquan;Ye, Qifa
甲壳素水凝胶具有无毒、生物相容性、生物可降解性和类似生物组织的三维亲水性高分子网络结构等优点。然而，甲壳素水凝胶的机械强度相对较弱。构建具有高机械强度和良好生物相容性的甲壳素水凝胶是其在生物医学领域成功应用的关键。本文采用冻融法将甲壳素溶解于KOH/尿素水溶液中，再以KH 560为交联剂，在乙醇溶液中低温凝固，制备了双交联甲壳素水凝胶。所制备的甲壳素/KH 560（CK）水凝胶具有良好的透明性和韧性，具有压缩的纳米纤维网络和由甲壳素纳米纤维编织的多孔结构。优化后的CK水凝胶具有优异的力学性能（σ（B）= 1.92 ± 0.21 Mpa; ε（B）= 71 ± 5%）、高溶胀率、良好的血液相容性、生物相容性和生物降解性，满足生物医用材料的要求，在生物医学领域具有潜在的应用前景。
Chitin hydrogels have multiple advantages of nontoxicity, biocompatibility, biodegradability, and three-dimensional hydrophilic polymer network structure similar to the macromolecular biological tissue. However, the mechanical strength of chitin hydrogels is relatively weak. Construction of chitin hydrogels with high me-chanical strength and good biocompatibility is essential for the successful applications in biomedical field. Herein, we developed double crosslinked chitin hydrogels by dissolving chitin in KOH/urea aqueous solution with freezing-thawing process, then using KH560 as cross-linking agent and coagulating in ethanol solution at low temperature. The obtained chitin/ KH560 (CK) hydrogels displayed good transparency and toughness with compressed nanofibrous network and porous structure woven with chitin nanofibers. Moreover, the optimal CK hydrogels exhibited excellent mechanical properties (sigma(b) = 1.92 +/- 0.21 Mpa; epsilon(b) = 71 +/- 5 %), high swelling ratio, excellent blood compatibility, biocompatibility and biodegradability, which fulfill the requirements of biomedical materials and showing potential applications in biomedicine.