Differential functions of lateral and medial rostral prefrontal cortex (area 10) revealed by brain-behavior associations
Differential functions of lateral and medial rostral prefrontal cortex (area 10) revealed by brain-behavior associations
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DOI：
10.1093/cercor/bhj113
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发表时间：
2006-12-01
期刊：
影响因子：
3.7
通讯作者：
Burgess, Paul W.
中科院分区：
文献类型：
--
作者：
Gilbert, Sam J.;Spengler, Stephanie;Burgess, Paul W.
我们分析了104个使用正电子的神经成像研究的行为数据。发射断层扫描或功能性磁共振成像报告了吻侧前额叶皮层（PFC）的激活峰，接近Brodmann区10。激活峰的绝对x坐标分布（即x坐标与半球无关）与单峰正态分布明显不同，反映了外侧和内侧亚区不同的激活簇。这两个集群与不同的行为数据模式相关联。横向激活与实验条件和对照条件之间的对比有关，实验条件下的反应时间（RTs）较慢。内侧激活与实验条件下RTs比控制条件下更快的对比有关。这些发现对吻侧PFC功能的理论提出了重要的限制。
We analyzed the behavioral data from 104 neuroimaging studies using positron. emission tomography or functional magnetic resonance imaging that reported activation peaks in rostral prefrontal Cortex (PFC), approximating Brodmann's area 10. The distribution of absolute x coordinates of activation peaks (i.e., x coordinate regardless of hemisphere) differed significantly from a unimodal normal distribution, reflecting distinct clusters of activation in lateral and medial subregions. These 2 clusters were associated with different patterns of behavioral data. Lateral activations were associated with contrasts between experimental and control conditions where response times (RTs) were slower in the experimental condition. Medial activations were associated with contrasts where RTs were, if anything, faster in experimental than control conditions. These findings place important constraints on theories of rostral PFC functions.