Cerebral glucose metabolism associated with a fear network in panic disorder
Cerebral glucose metabolism associated with a fear network in panic disorder
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DOI：
10.1097/00001756-200506210-00010
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发表时间：
2005-06-21
期刊：
影响因子：
1.7
通讯作者：
Kuboki, T
中科院分区：
文献类型：
--
作者：
Sakai, Y;Kumano, H;Kuboki, T
本研究采用正电子发射断层扫描评估惊恐障碍患者的脑糖代谢。采用基于体素分析的f -18-氟脱氧葡萄糖正电子发射断层扫描，比较了12例在正电子发射断层扫描获取期间没有惊恐发作的非药物惊恐障碍患者与22名健康对照者的区域脑葡萄糖利用情况。惊恐障碍患者在扫描前表现出明显的高度焦虑状态，并且在双侧杏仁核、海马、丘脑、中脑、尾桥、髓质和小脑中表现出明显高于对照组的葡萄糖摄取水平。这些结果为人类患者提供了第一个功能性神经影像学支持，以杏仁核为基础的恐惧网络为重点的恐慌症的神经解剖学假说。神经报告16:927-931 (c) 2005 Lippincott Williams & Wilkins。
The present study was performed to assess cerebral glucose metabolism in patients with panic disorder using positron emission tomography. F-18-fluorodeoxyglucose positron emission tomography with voxel-based analysis was used to compare regional brain glucose utilization in 12 nonmedicated panic disorder patients, without their experiencing panic attacks during positron emission tomography acquisition, with that in 22 healthy controls. Panic disorder patients showed appreciably high state anxiety before scanning, and exhibited significantly higher levels of glucose uptake in the bilateral amygdala, hippocampus, and thalamus, and in the midbrain, caudal pons, medulla, and cerebellum than controls. These results provided the first functional neuroimaging support in human patients for the neuroanatomical hypothesis of panic disorder focusing on the amygdala-based fear network. NeuroReport 16:927-931 (c) 2005 Lippincott Williams & Wilkins.