Ready for prime time? Dual tracer PET and SPECT imaging.
Ready for prime time? Dual tracer PET and SPECT imaging.
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准备好迎接黄金时段了吗？
DOI：
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发表时间：
2012
影响因子：
2.5
通讯作者：
G. Fakhri
中科院分区：
文献类型：
--
作者：
G. Fakhri
双同位素单光子发射计算机断层扫描(SPECT)和双示踪正电子发射计算机断层扫描(PET)在儿童和成人的脑、心脏和肿瘤学成像的许多领域具有巨大的临床和分子应用潜力，因为它允许在相同的生理和物理条件下探索不同的生理和分子功能(例如，血流、神经传递、代谢、细胞凋亡、血管生成)。当所研究的生理功能相互依赖(例如，灌流和新陈代谢)时，这是至关重要的，因此需要在相同的条件下同时进行评估，并且可以极大地减少与可能在采集之间发生变化的物理因素(例如，人体受试者或动物运动、衰减图随时间的变化)相关的量化误差，如本文社论中所详细描述的。同时对双核素SPECT、双示踪PET和双SPECT/PET的临床应用潜力进行了探讨和总结。本期《美国医学杂志》(http://www.ajnmmi.us)，Chapman et al.探讨同步和顺序SPECT/PET成像的可行性，并得出结论：在有PET放射性示踪剂存在的情况下，来自511keV光子的下散射和串扰排除了获取有用的SPECT信息的可能性。他们报告了一种替代策略，包括在混合microPET/SPECT/CT扫描仪中进行顺序SPECT和PET研究，这种扫描仪现在广泛用于分子成像。他们在一个由96孔板组成的模型中验证了他们的方法，其中包括可变的(99m)Tc和(18)F浓度，并说明了这种方法在两项连续的SPECT-PET/CT研究中的实用性，这两项研究包括(99m)Tc-MAA/(18)F-NaF和(99m)Tc-Pentetate/(18)F-NaF。这些方法需要被证明是可重复性的、准确的和对实验条件变化的健壮，然后才能被分子成像界接受，并在常规的分子microPET和microSPECT探索中实施。虽然目前这些方法还没有被分子成像界接受为标准程序，但这些方法有可能为新的SPECT/PET探索开辟道路，从而在类似的生理条件下研究活体动物的分子机制和途径。虽然这些方法对于临床环境来说仍然为时过早，但一旦在小动物和大动物模型中被证明是准确和精确的，这些方法就可以扩展到临床研究。
Dual isotope single photon emission computed tomography (SPECT) and dual tracer positron emission tomography (PET) imaging have great potential in clinical and molecular applications in the pediatric as well as the adult populations in many areas of brain, cardiac, and oncologic imaging as it allows the exploration of different physiological and molecular functions (e.g., perfusion, neurotransmission, metabolism, apoptosis, angiogenesis) under the same physiological and physical conditions. This is crucial when the physiological functions studied depend on each other (e.g., perfusion and metabolism) hence requiring simultaneous assessment under identical conditions, and can reduce greatly the quantitation errors associated with physical factors that can change between acquisitions (e.g., human subject or animal motion, change in the attenuation map as a function of time) as is detailed in this editorial. The clinical potential of simultaneous dual isotope SPECT, dual tracer PET and dual SPECT/PET imaging are explored and summarized. In this issue of AJNMMI (http://www.ajnmmi.us), Chapman et al. explore the feasibility of simultaneous and sequential SPECT/PET imaging and conclude that down-scatter and crosstalk from 511 keV photons preclude obtaining useful SPECT information in the presence of PET radiotracers. They report on an alternative strategy that consists of performing sequential SPECT and PET studies in hybrid microPET/SPECT/CT scanners, now widely available for molecular imaging. They validate their approach in a phantom consisting of a 96-well plate with variable (99m)Tc and (18)F concentrations and illustrate the utility of such approaches in two sequential SPECT-PET/CT studies that include (99m)Tc-MAA/(18)F-NaF and (99m)Tc-Pentetate/(18)F-NaF. These approaches will need to be proven reproducible, accurate and robust to variations in the experimental conditions before they can be accepted by the molecular imaging community and be implemented in routine molecular microPET and microSPECT explorations. Although currently not accepted as standard procedures in the molecular imaging community, such approaches have the potential to open the way to new SPECT/PET explorations that allow studying molecular mechanisms and pathways in the living animal under similar physiological conditions. Although still premature for the clinical setting, these approaches can be extended to clinical research once proven accurate and precise in vivo in small and large animal models.
同时 123I/99mTc 脑 SPECT 中的绝对活性定量。
DOI：
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发表时间：
2001
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
ElFakhri,G;Moore,SC;Maksud,P;Aurengo,A;Kijewski,MF
通讯作者：
Kijewski,MF