A γ-Fluoro β-Acetoxypropyl Sulfonium Salt as an Equivalent of a (Fluoromethyl)vinyl Sulfonium Salt: Reagent for the Facile Synthesis of Monofluoromethylated Cyclopropanes or Aziridines
A γ-Fluoro β-Acetoxypropyl Sulfonium Salt as an Equivalent of a (Fluoromethyl)vinyl Sulfonium Salt: Reagent for the Facile Synthesis of Monofluoromethylated Cyclopropanes or Aziridines
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γ-氟β-乙酰氧基丙基锍盐作为（氟甲基）乙烯基锍盐的等价物：用于轻松合成单氟甲基化环丙烷或氮丙啶的试剂
DOI：
10.1055/s-0037-1611000
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发表时间：
2018
期刊：
影响因子：
2
通讯作者：
Takeshi Hanamoto
中科院分区：
文献类型：
--
作者：
Yuuri Fujiwara;Ryuhei Muta;Keiichi Sato;Hiroaki Haramura;Yasunori Yamada;Takeshi Hanamoto
以γ-氟β-乙酰氧基丙基磺酸盐为前驱体，在温和的碱性条件下原位制备β-单氟甲基化乙烯基磺酸盐，在碱性条件下与多种活性亚甲基化合物或叔砜酰胺反应，以优异的收率生成相应的单氟甲基化三元环。这种新的磺化试剂可以很容易地接触到各种重要的单氟甲基化有机化合物。
A β-monofluoromethylated vinyl sulfonium salt, prepared in situ from a precursor γ-fluoro β-acetoxypropyl sulfonium salt under mild basic conditions, reacted with a lvariety of active methylene compounds or a primary sulfone amide under basic conditions to provide the corresponding monofluoromethylated three-membered rings in good-to-excellent yields. This new sulfonium reagent should permit easy access to a variety of important monofluoromethylated organic compounds.