Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors
Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors
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DOI：
10.1016/j.biomaterials.2007.08.050
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发表时间：
2008-02-01
期刊：
影响因子：
14
通讯作者：
Yang, Victor C.
中科院分区：
文献类型：
--
作者：
Chertok, Beata;Moffat, Bradford A.;Yang, Victor C.
本研究探索了利用氧化铁纳米颗粒作为微创、mri监测的脑肿瘤磁靶向药物递送载体的可能性。体外测定的流体动力直径约为100nm，饱和磁化强度为94 emu/g Fe， T-2弛豫度为43 s(-1) mM(-1)，表明纳米颗粒适用于此目的。MRI定量研究了磁靶向对原位9l -胶质瘤大鼠肿瘤内纳米颗粒聚集程度和选择性的影响。在0T（对照组）或0.4 T（实验组）的磁场密度下，给动物静脉注射纳米颗粒（12mg Fe/kg），持续30分钟。在给予纳米颗粒之前和磁靶向后立即以1 It间隔4h获得MR图像。图像分析显示，磁性靶向诱导胶质瘤暴露于磁性纳米颗粒的总量比非靶向肿瘤增加了5倍（p = 0.005），纳米颗粒在胶质瘤中积累的目标选择性指数比正常大脑增加了3.6倍（p = 0.025）。综上所述，磁靶向可以显著增强胶质肉瘤中氧化铁纳米颗粒的积累，并通过磁共振成像成功量化。因此，这些纳米颗粒似乎是一种有希望的胶质瘤靶向药物递送载体。(c) 2007 Elsevier Ltd.版权所有。
This study explored the possibility of utilizing iron oxide nanoparticles as a drug delivery vehicle for minimally invasive, MRI-monitored magnetic targeting of brain tumors. In vitro determined hydrodynamic diameter of similar to 100nm, saturation magnetization of 94 emu/g Fe and T-2 relaxivity of 43 s(-1) mM(-1) of the nanoparticles suggested their applicability for this purpose. In vivo effect of magnetic targeting on the extent and selectivity of nanoparticle accumulation in tumors of rats harboring orthotopic 9L-gliosarcomas was quantified with MRI. Animals were intravenously injected with nanoparticles (12mg Fe/kg) under a magnetic field density of 0T (control) or 0.4 T (experimental) applied for 30 min. MR images were acquired prior to administration of nanoparticles and immediately after magnetic targeting at I It intervals for 4h. Image analysis revealed that magnetic targeting induced a 5-fold increase in the total glioma exposure to magnetic nanoparticles over non-targeted tumors (p = 0.005) and a 3.6-fold enhancement in the target selectivity index of nanoparticle accumulation in glioma over the normal brain (p = 0.025). In conclusion, accumulation of iron oxide nanoparticles in gliosarcomas can be significantly enhanced by magnetic targeting and successfully quantified by MR imaging. Hence, these nanoparticles appear to be a promising vehicle for glioma-targeted drug delivery. (c) 2007 Elsevier Ltd. All rights reserved.