SMOKERS OF LOW-YIELD CIGARETTES DO NOT CONSUME LESS NICOTINE
SMOKERS OF LOW-YIELD CIGARETTES DO NOT CONSUME LESS NICOTINE
复制标题
DOI：
10.1056/nejm198307213090303
复制
发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
OSMAN, AL
中科院分区：
文献类型：
--
作者：
BENOWITZ, NL;HALL, SM;OSMAN, AL
广告表明，吸烟者的香烟低尼古丁暴露于更少的尼古丁和焦油。尼古丁产量是用吸烟机测量的，但机器不像人那样吸烟。本文测定了272名不同品牌香烟的实际尼古丁含量和实际尼古丁摄入量，并与吸烟机测定的尼古丁和焦油量进行了比较。低产量卷烟的烟碱含量并不降低，实际上，烟草中的烟碱浓度与吸烟机测定的浓度呈负相关（r =-0.53，P < 0.05）。血液中可替宁浓度与每天吸烟的数量相关，但与吸烟机测量的尼古丁产量无关。尼古丁产量仅占血液可替宁总方差的3.8-5.0%。低尼古丁香烟的吸烟者并没有消耗更少的尼古丁。
Advertisements suggest that smokers of cigarettes low in nicotine are exposed to less nicotine and tar. Nicotine yields are measured with smoking machines, but machines do not smoke cigarettes as people do. The actual nicotine content of commercial cigarettes with different nicotine and tar yields as determined with smoking machines and actual nicotine intake as indicated by blood concentrations of its metabolite, cotinine, were measured in 272 subjects smoking various brands of cigarettes. Low-yield cigarette tabacco did not contain less nicotine; in fact, the nicotine concentration in tobacco inversely correlated (r = -0.53, P < 0.05) with the concentration measured by smoking machines. Blood cotinine concentrations correlated with the number of cigarettes smoked/day but not with the nicotine yield measured by smoking machines. Only 3.8-5.0% of the total variance in blood cotinine was contributed by nicotine yield. Smokers of low-nicotine cigarettes did not consume less nicotine.