Improved tumour localisation using indium-111 labelled antibodies.
Improved tumour localisation using indium-111 labelled antibodies.
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使用 indium-111 标记抗体改善肿瘤定位。
DOI：
10.1136/bmj.287.6386.167
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
S. Chandler
中科院分区：
文献类型：
--
作者：
D. Fairweather;A. Bradwell;P. Dykes;A. Vaughan;S. Watson;S. Chandler
用放射性铟（111 In）或碘（131 I）标记抗癌胚抗原（CEA）的免疫球蛋白G（IgG）抗体，比较它们在定位CEA产生肿瘤中的价值。11例给予111 In-抗CEA的患者有31个肿瘤，通过所有技术的组合来判断。其中28例用~（111）In-抗CEA检测，26例用常规临床技术检测。其中5例患者还接受了131 I-抗CEA。这些患者有15个肿瘤区域。111 In探测到13个，131 I探测到8个。111 In还在扫描中产生了更好的信噪比，从而更确定地显示了病变。此外，111 In同位素在肿瘤区域的累积时间比131 I长得多。两种同位素的吸收剂量（全身）相似。结果表明，使用111 In代替131 I作为放射性标记大大改善了抗体扫描，并且应该允许检测更小或更深的病变。
Immunoglobulin G (IgG) antibodies to carcinoembryonic antigen (CEA) were labelled with radioactive indium (111In) or iodine (131I) and a comparison made of their value in locating CEA producing tumours. Eleven patients given 111In-anti-CEA had 31 tumours as judged by a combination of all techniques. Of these, 28 were detected by 111In-anti-CEA and 26 by conventional clinical techniques. Five of the patients also received 131I-anti-CEA. These patients had 15 tumour areas. Thirteen were detected by 111In and eight by 131I. 111In also produced a better signal to noise ratio in the scans and thereby showed lesions with greater certainty. In addition, the 111In isotope continued to accumulate in the tumour areas for considerably longer than 131I. Absorbed doses (whole body) were similar for both isotopes. The results show that antibody scanning is greatly improved by using 111In as the radiolabel in place of 131I and should allow the detection of smaller or deeper lesions.